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• W1790394413 abstract "Abstract Aim Primary Sjögren's syndrome ( pSS ) is an autoimmune disease affecting exocrine glands. Both autoreactive T cells and B cells are involved in the development of pSS , but their exact contribution to the pathogenesis is not clear. Here, we aimed to investigate the association of B‐cell activating factor ( BAFF ) and interleukin ( IL )‐17A with subphenotypes of pSS . Methods Peripheral blood samples were collected from 31 pSS patients and 28 healthy controls. The serum levels of BAFF and IL ‐17A were quantified by sandwich ELISA . Results The increased circulating BAFF levels are associated with higher immunoglobulin G (IgG) levels ( P = 0.0167) and anti‐Ro/ SS antigen A autoantibody ( P = 0.032), while the elevated circulating levels of IL ‐17A are associated with lower C3 levels ( P = 0.0213) and higher focus score of salivary gland tissue ( P = 0.002). Conclusion Our results show that BAFF and IL ‐17A are associated with different subphenotypes of pSS , suggesting both humoral and cellular immune response are involved in the pathogenesis of pSS ." @default.
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• W1790394413 date "2015-05-04" @default.
• W1790394413 modified "2023-10-16" @default.
• W1790394413 title "Association of BAFF and IL-17A with subphenotypes of primary Sjögren's syndrome" @default.
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• W1790394413 doi "https://doi.org/10.1111/1756-185x.12569" @default.
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