Matches in SemOpenAlex for { <https://semopenalex.org/work/W179093910> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W179093910 endingPage "6" @default.
- W179093910 startingPage "51" @default.
- W179093910 abstract "We observed the time course of hemodynamic and pathological changes after single injection of various dose of monocrotaline (Mct) to investigate the dose-dependent effects on the induction and regression of pulmonary hypertension in rat: A hundred four-week old male Sprague-Dowley rats were divided into five groups and each group, except the control group, received 10 mg, 20 mg, 30 mg or 40 mg/kg Mct, respectively. The experimental periods were nine weeks after monocrotaline injection. At the third, sixth and ninth week after treatment, the survival rate, cardiac catheterization and pathological changes were evaluated. All rats given 30 mg or 40 mg per kg of Mct died within five weeks. In the third week after the treatment, elevation of the right ventricular systolic pressure (RVSP), the grade of right ventricular hypertrophy (RVH) and histological change showed no significant difference among rats receiving 20, 30 or 40 mg/kg Mct injection. Almost all rats given 10 mg or 20 mg/kg Mct survived through the experimental period of nine weeks. Rats given 10 mg per kg of Mct did not develop pulmonary hypertension or pathological abnormalities in the lungs. Rats receiving 20 mg/kg Mct showed transient elevation of RVSP, RVH and pulmonary histological changes in the early phase, but these findings regressed by the ninth week of the experiment. Namely, rats which received 20 mg pr kg of Mct revealed transient elevation of right ventricular systolic pressure, right ventricular hypertrophy and pulmonary histological changes only in the early phase and these changes regressed gradually thereafter. These results indicate some kind of transient and reversible factor may play a role in the development and regression of Mct-induced pulmonary hypertension in rats." @default.
- W179093910 created "2016-06-24" @default.
- W179093910 creator A5009883974 @default.
- W179093910 creator A5024660569 @default.
- W179093910 creator A5026951998 @default.
- W179093910 creator A5037470884 @default.
- W179093910 creator A5039238235 @default.
- W179093910 creator A5043074185 @default.
- W179093910 creator A5043551395 @default.
- W179093910 creator A5046392101 @default.
- W179093910 creator A5064850034 @default.
- W179093910 creator A5076938236 @default.
- W179093910 date "1989-01-01" @default.
- W179093910 modified "2023-09-26" @default.
- W179093910 title "[Effects of various doses of monocrotaline administration on the development of pulmonary hypertension and its regression in rats]." @default.
- W179093910 cites W1846732345 @default.
- W179093910 cites W1991976084 @default.
- W179093910 cites W2046780042 @default.
- W179093910 cites W2260163481 @default.
- W179093910 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2501548" @default.
- W179093910 hasPublicationYear "1989" @default.
- W179093910 type Work @default.
- W179093910 sameAs 179093910 @default.
- W179093910 citedByCount "1" @default.
- W179093910 crossrefType "journal-article" @default.
- W179093910 hasAuthorship W179093910A5009883974 @default.
- W179093910 hasAuthorship W179093910A5024660569 @default.
- W179093910 hasAuthorship W179093910A5026951998 @default.
- W179093910 hasAuthorship W179093910A5037470884 @default.
- W179093910 hasAuthorship W179093910A5039238235 @default.
- W179093910 hasAuthorship W179093910A5043074185 @default.
- W179093910 hasAuthorship W179093910A5043551395 @default.
- W179093910 hasAuthorship W179093910A5046392101 @default.
- W179093910 hasAuthorship W179093910A5064850034 @default.
- W179093910 hasAuthorship W179093910A5076938236 @default.
- W179093910 hasConcept C126322002 @default.
- W179093910 hasConcept C164705383 @default.
- W179093910 hasConcept C167414201 @default.
- W179093910 hasConcept C178853913 @default.
- W179093910 hasConcept C207886595 @default.
- W179093910 hasConcept C26635844 @default.
- W179093910 hasConcept C2779376020 @default.
- W179093910 hasConcept C2780930700 @default.
- W179093910 hasConcept C71924100 @default.
- W179093910 hasConcept C84393581 @default.
- W179093910 hasConceptScore W179093910C126322002 @default.
- W179093910 hasConceptScore W179093910C164705383 @default.
- W179093910 hasConceptScore W179093910C167414201 @default.
- W179093910 hasConceptScore W179093910C178853913 @default.
- W179093910 hasConceptScore W179093910C207886595 @default.
- W179093910 hasConceptScore W179093910C26635844 @default.
- W179093910 hasConceptScore W179093910C2779376020 @default.
- W179093910 hasConceptScore W179093910C2780930700 @default.
- W179093910 hasConceptScore W179093910C71924100 @default.
- W179093910 hasConceptScore W179093910C84393581 @default.
- W179093910 hasIssue "1" @default.
- W179093910 hasLocation W1790939101 @default.
- W179093910 hasOpenAccess W179093910 @default.
- W179093910 hasPrimaryLocation W1790939101 @default.
- W179093910 hasRelatedWork W1973262796 @default.
- W179093910 hasRelatedWork W1976409316 @default.
- W179093910 hasRelatedWork W1988466345 @default.
- W179093910 hasRelatedWork W2000114681 @default.
- W179093910 hasRelatedWork W2016093097 @default.
- W179093910 hasRelatedWork W2036381550 @default.
- W179093910 hasRelatedWork W2051765062 @default.
- W179093910 hasRelatedWork W2125410963 @default.
- W179093910 hasRelatedWork W2144340482 @default.
- W179093910 hasRelatedWork W2385756620 @default.
- W179093910 hasVolume "27" @default.
- W179093910 isParatext "false" @default.
- W179093910 isRetracted "false" @default.
- W179093910 magId "179093910" @default.
- W179093910 workType "article" @default.