Matches in SemOpenAlex for { <https://semopenalex.org/work/W179157422> ?p ?o ?g. }
- W179157422 endingPage "967" @default.
- W179157422 startingPage "961" @default.
- W179157422 abstract "The inhibitor of DNA-methylation, 5-azacytidine (5- AzaC ) induced the appearance of cytokeratin-containing cells in several mesenchymal cell lines such as teratocarcinoma-derived fibroblasts, preadipocytes and myoblasts, NIH-3T3 fibroblasts and human embryonic fibroblasts. At optimal 5- AzaC concentrations the proportion of such cells was in the range of 10(-1) compared with 10(-6) -10(-4) in non-treated cultures. Dose-response curves indicated that the induction of cytokeratin was the result of an interaction of the drug with few targets. Stable, mature, keratinocyte cell lines, as well as lines of myoblasts and astrocytes, could be isolated from a teratocarcinoma-derived preadipocyte line, showing that 5- AzaC is able to provoke a wide range of complete phenotypic conversions. In these cell lines, the intermediate filaments corresponded to the morphological phenotype. Altogether, the results suggest that 5- AzaC preferentially activates certain genes." @default.
- W179157422 created "2016-06-24" @default.
- W179157422 creator A5043205872 @default.
- W179157422 creator A5063336888 @default.
- W179157422 creator A5088402059 @default.
- W179157422 date "1984-05-01" @default.
- W179157422 modified "2023-10-18" @default.
- W179157422 title "5-Azacytidine is able to induce the conversion of teratocarcinoma-derived mesenchymal cells into epithelia cells." @default.
- W179157422 cites W1516227994 @default.
- W179157422 cites W1519345765 @default.
- W179157422 cites W1530776845 @default.
- W179157422 cites W1577079088 @default.
- W179157422 cites W1865658459 @default.
- W179157422 cites W1969023545 @default.
- W179157422 cites W1972941987 @default.
- W179157422 cites W1975287171 @default.
- W179157422 cites W1980206616 @default.
- W179157422 cites W1982548447 @default.
- W179157422 cites W1987885030 @default.
- W179157422 cites W1991808599 @default.
- W179157422 cites W1992288855 @default.
- W179157422 cites W1995789984 @default.
- W179157422 cites W1996785251 @default.
- W179157422 cites W1999207609 @default.
- W179157422 cites W2016693266 @default.
- W179157422 cites W2018289835 @default.
- W179157422 cites W2022608661 @default.
- W179157422 cites W2027782583 @default.
- W179157422 cites W2031131841 @default.
- W179157422 cites W2032320245 @default.
- W179157422 cites W2034602099 @default.
- W179157422 cites W2045934824 @default.
- W179157422 cites W2050567744 @default.
- W179157422 cites W2054818866 @default.
- W179157422 cites W2057294736 @default.
- W179157422 cites W2058475255 @default.
- W179157422 cites W2058835187 @default.
- W179157422 cites W2074024882 @default.
- W179157422 cites W2100837269 @default.
- W179157422 cites W2101108802 @default.
- W179157422 cites W2108283430 @default.
- W179157422 cites W2111817213 @default.
- W179157422 cites W2145750252 @default.
- W179157422 cites W2176878832 @default.
- W179157422 cites W2417499034 @default.
- W179157422 cites W2418336370 @default.
- W179157422 cites W4236497821 @default.
- W179157422 cites W4327766605 @default.
- W179157422 doi "https://doi.org/10.1002/j.1460-2075.1984.tb01914.x" @default.
- W179157422 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/557458" @default.
- W179157422 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6203746" @default.
- W179157422 hasPublicationYear "1984" @default.
- W179157422 type Work @default.
- W179157422 sameAs 179157422 @default.
- W179157422 citedByCount "52" @default.
- W179157422 countsByYear W1791574222012 @default.
- W179157422 countsByYear W1791574222013 @default.
- W179157422 countsByYear W1791574222018 @default.
- W179157422 countsByYear W1791574222019 @default.
- W179157422 countsByYear W1791574222020 @default.
- W179157422 countsByYear W1791574222023 @default.
- W179157422 crossrefType "journal-article" @default.
- W179157422 hasAuthorship W179157422A5043205872 @default.
- W179157422 hasAuthorship W179157422A5063336888 @default.
- W179157422 hasAuthorship W179157422A5088402059 @default.
- W179157422 hasBestOaLocation W1791574221 @default.
- W179157422 hasConcept C104317684 @default.
- W179157422 hasConcept C127716648 @default.
- W179157422 hasConcept C145103041 @default.
- W179157422 hasConcept C148738053 @default.
- W179157422 hasConcept C150194340 @default.
- W179157422 hasConcept C153911025 @default.
- W179157422 hasConcept C190727270 @default.
- W179157422 hasConcept C198826908 @default.
- W179157422 hasConcept C203014093 @default.
- W179157422 hasConcept C204232928 @default.
- W179157422 hasConcept C207200792 @default.
- W179157422 hasConcept C2779012181 @default.
- W179157422 hasConcept C2780381497 @default.
- W179157422 hasConcept C2908788973 @default.
- W179157422 hasConcept C3763915 @default.
- W179157422 hasConcept C54355233 @default.
- W179157422 hasConcept C55493867 @default.
- W179157422 hasConcept C81885089 @default.
- W179157422 hasConcept C86803240 @default.
- W179157422 hasConcept C95444343 @default.
- W179157422 hasConceptScore W179157422C104317684 @default.
- W179157422 hasConceptScore W179157422C127716648 @default.
- W179157422 hasConceptScore W179157422C145103041 @default.
- W179157422 hasConceptScore W179157422C148738053 @default.
- W179157422 hasConceptScore W179157422C150194340 @default.
- W179157422 hasConceptScore W179157422C153911025 @default.
- W179157422 hasConceptScore W179157422C190727270 @default.
- W179157422 hasConceptScore W179157422C198826908 @default.
- W179157422 hasConceptScore W179157422C203014093 @default.
- W179157422 hasConceptScore W179157422C204232928 @default.
- W179157422 hasConceptScore W179157422C207200792 @default.
- W179157422 hasConceptScore W179157422C2779012181 @default.