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- W1791884122 abstract "Increasing hypoxia with altitude ascent is a potentially serious problem for patients with hypoxemic chronic airway obstruction (CAO) at sea level. We developed a hypoxia-altitude simulation test (HAST) to assess acute cardiopulmonary responses to the inhalation of hypoxic gas mixtures (equivalent to the inspired oxygen tension (PO2) present at 5,000, 8,000, and 10,000 feet above sea level) alone and in combination with supplemental oxygen (O2). Twenty-two subjects with stable normocapnic CAO were studied at sea level with a computer-based system that measured on-line, breath-by-breath resting ventilatory and gas exchange variables. Subjects breathed 20.9% (baseline), 17.1, 15.1, 13.9, and 20.9% (recovery) O2, and measurements were obtained once a “steady state” was reached at each level. Steady-state arterial PO2 (PaO2) and O2 saturation, alveolar PO2, and alveolar-to-arterial PO2 gradient decreased markedly during successive hypoxic levels, whereas arterial carbon dioxide tensions decreased only modestl..." @default.
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- W1791884122 date "2015-05-14" @default.
- W1791884122 modified "2023-09-24" @default.
- W1791884122 title "Hypoxia-Altitude Simulation Test" @default.
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