Matches in SemOpenAlex for { <https://semopenalex.org/work/W1791888878> ?p ?o ?g. }
- W1791888878 endingPage "13" @default.
- W1791888878 startingPage "1" @default.
- W1791888878 abstract "While a plethora of extracellular molecules exist that modulate cellular functions via binding to membrane receptors inside the cell, their actions are mediated by relatively few signalling mechanisms. One of these is activation of phosphatidylinositol 3-kinase (PI-3K), which results in the generation of a membrane-restricted second messenger, polyphosphatidylinositides containing a 3´-phosphate. How these molecules transduced the effects of agonists of PI-3K was unclear until the recent discovery that several protein kinases become activated upon exposure to 3´-phosphorylated inositol lipids. These enzymes include protein kinase B (PKB)/AKT and PtdIns(3,4,5)P3-dependent kinases 1 and 2, the first two of which interact with 3´-phosphorylated phosphoinositides via pleckstrin homology domains. Once targeted to the membrane by this motif, PKB becomes phosphorylated at two residues, which relieves intermolecular inhibition, allowing the activated complex to dissociate and modify its targets. Identification of these substrates is the subject of intensive research, since at least one must play a key role in suppressing apoptosis, as demonstrated by expression of activated alleles of PKB. The generation of effective transdominant mutants, coupled with genetic analysis of the protein kinase in simpler organisms, should help in elucidating outstanding questions in the functions, targets and regulation of this important mediator of PI-3K signalling." @default.
- W1791888878 created "2016-06-24" @default.
- W1791888878 creator A5043927370 @default.
- W1791888878 creator A5067990066 @default.
- W1791888878 creator A5082156574 @default.
- W1791888878 date "1998-10-01" @default.
- W1791888878 modified "2023-10-01" @default.
- W1791888878 title "Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation" @default.
- W1791888878 cites W106792807 @default.
- W1791888878 cites W119017381 @default.
- W1791888878 cites W123706286 @default.
- W1791888878 cites W1492349549 @default.
- W1791888878 cites W1493793163 @default.
- W1791888878 cites W1513878541 @default.
- W1791888878 cites W1529396499 @default.
- W1791888878 cites W1551443142 @default.
- W1791888878 cites W165132588 @default.
- W1791888878 cites W1726025741 @default.
- W1791888878 cites W177380973 @default.
- W1791888878 cites W1858533191 @default.
- W1791888878 cites W1876033686 @default.
- W1791888878 cites W1914067219 @default.
- W1791888878 cites W1931082872 @default.
- W1791888878 cites W1949632792 @default.
- W1791888878 cites W1954313480 @default.
- W1791888878 cites W1970529208 @default.
- W1791888878 cites W1972307668 @default.
- W1791888878 cites W1973837499 @default.
- W1791888878 cites W1974241409 @default.
- W1791888878 cites W1978810830 @default.
- W1791888878 cites W1979909416 @default.
- W1791888878 cites W1979913537 @default.
- W1791888878 cites W1983566655 @default.
- W1791888878 cites W1985969245 @default.
- W1791888878 cites W1988706792 @default.
- W1791888878 cites W1989294105 @default.
- W1791888878 cites W1992393431 @default.
- W1791888878 cites W1993205500 @default.
- W1791888878 cites W1993669933 @default.
- W1791888878 cites W1993963200 @default.
- W1791888878 cites W1995757037 @default.
- W1791888878 cites W1997799275 @default.
- W1791888878 cites W1997954665 @default.
- W1791888878 cites W1999012962 @default.
- W1791888878 cites W1999163644 @default.
- W1791888878 cites W1999447199 @default.
- W1791888878 cites W2000552194 @default.
- W1791888878 cites W2000653179 @default.
- W1791888878 cites W2004078164 @default.
- W1791888878 cites W2008291690 @default.
- W1791888878 cites W2008940139 @default.
- W1791888878 cites W2013238591 @default.
- W1791888878 cites W2016135608 @default.
- W1791888878 cites W2017641447 @default.
- W1791888878 cites W2017878931 @default.
- W1791888878 cites W2018800747 @default.
- W1791888878 cites W2021075508 @default.
- W1791888878 cites W2022032271 @default.
- W1791888878 cites W2023278519 @default.
- W1791888878 cites W2023348498 @default.
- W1791888878 cites W2028268047 @default.
- W1791888878 cites W2028365267 @default.
- W1791888878 cites W2028742041 @default.
- W1791888878 cites W2030573603 @default.
- W1791888878 cites W2032983732 @default.
- W1791888878 cites W2034397029 @default.
- W1791888878 cites W2035147500 @default.
- W1791888878 cites W2035408994 @default.
- W1791888878 cites W2037758170 @default.
- W1791888878 cites W2038594687 @default.
- W1791888878 cites W2039355845 @default.
- W1791888878 cites W2041926656 @default.
- W1791888878 cites W2043395027 @default.
- W1791888878 cites W2044868069 @default.
- W1791888878 cites W2047287528 @default.
- W1791888878 cites W2048121649 @default.
- W1791888878 cites W2048596844 @default.
- W1791888878 cites W204878250 @default.
- W1791888878 cites W2050054840 @default.
- W1791888878 cites W2050498522 @default.
- W1791888878 cites W2056270776 @default.
- W1791888878 cites W2056856045 @default.
- W1791888878 cites W2058138221 @default.
- W1791888878 cites W2059221693 @default.
- W1791888878 cites W2059692699 @default.
- W1791888878 cites W2062083574 @default.
- W1791888878 cites W2064242629 @default.
- W1791888878 cites W2066457776 @default.
- W1791888878 cites W2069862519 @default.
- W1791888878 cites W2071075259 @default.
- W1791888878 cites W2074830772 @default.
- W1791888878 cites W2075097891 @default.
- W1791888878 cites W2077478539 @default.
- W1791888878 cites W2078297328 @default.
- W1791888878 cites W2079123009 @default.
- W1791888878 cites W2079357365 @default.
- W1791888878 cites W2081698610 @default.
- W1791888878 cites W2087904456 @default.