FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1792138387> ?p ?o ?g. }

• W1792138387 endingPage "21" @default.
• W1792138387 startingPage "21" @default.
• W1792138387 abstract "The CD38 transmembrane glycoprotein is an ADP-ribosyl cyclase that moonlights as a receptor in cells of the immune system. Both functions are independently implicated in numerous areas related to human health. This study originated from an inherent interest in studying CD38 in the cynomolgus monkey (Macaca fascicularis), a species closely related to humans that also represents a cogent animal model for the biomedical analysis of CD38. A cDNA was isolated from cynomolgus macaque peripheral blood leukocytes and is predicted to encode a type II membrane protein of 301 amino acids with 92% identity to human CD38. Both RT-PCR-mediated cDNA cloning and genomic DNA PCR surveying were possible with heterologous human CD38 primers, demonstrating the striking conservation of CD38 in these primates. Transfection of the cDNA coincided with: (i) surface expression of cynomolgus macaque CD38 by immunofluorescence; (ii) detection of ~42 and 84 kDa proteins by Western blot and (iii) the appearance of ecto-enzymatic activity. Monoclonal antibodies were raised against the cynomolgus CD38 ectodomain and were either species-specific or cross-reactive with human CD38, in which case they were directed against a common disulfide-requiring conformational epitope that was mapped to the C-terminal disulfide loop. This multi-faceted characterization of CD38 from cynomolgus macaque demonstrates its high genetic and biochemical similarities with human CD38 while the immunological comparison adds new insights into the dominant epitopes of the primate CD38 ectodomain. These results open new prospects for the biomedical and pharmacological investigations of this receptor-enzyme." @default.
• W1792138387 created "2016-06-24" @default.
• W1792138387 creator A5007447330 @default.
• W1792138387 creator A5027094360 @default.
• W1792138387 creator A5037122776 @default.
• W1792138387 creator A5045833196 @default.
• W1792138387 creator A5051896063 @default.
• W1792138387 creator A5052988199 @default.
• W1792138387 creator A5066772857 @default.
• W1792138387 creator A5088765980 @default.
• W1792138387 date "2004-01-01" @default.
• W1792138387 modified "2023-10-09" @default.
• W1792138387 cites W1243376384 @default.
• W1792138387 cites W1486393789 @default.
• W1792138387 cites W1506889278 @default.
• W1792138387 cites W1515039418 @default.
• W1792138387 cites W1517204282 @default.
• W1792138387 cites W1517749679 @default.
• W1792138387 cites W1523107744 @default.
• W1792138387 cites W1528361613 @default.
• W1792138387 cites W1532380457 @default.
• W1792138387 cites W1559286577 @default.
• W1792138387 cites W1566643819 @default.
• W1792138387 cites W1577723740 @default.
• W1792138387 cites W1914120156 @default.
• W1792138387 cites W1946011844 @default.
• W1792138387 cites W1966884256 @default.
• W1792138387 cites W1973881700 @default.
• W1792138387 cites W1980392536 @default.
• W1792138387 cites W1989917641 @default.
• W1792138387 cites W1993655001 @default.
• W1792138387 cites W1994777926 @default.
• W1792138387 cites W1995188461 @default.
• W1792138387 cites W1997101525 @default.
• W1792138387 cites W1997308033 @default.
• W1792138387 cites W1999644793 @default.
• W1792138387 cites W2003353539 @default.
• W1792138387 cites W2007102070 @default.
• W1792138387 cites W2008755938 @default.
• W1792138387 cites W2011678400 @default.
• W1792138387 cites W2012174792 @default.
• W1792138387 cites W2015906906 @default.
• W1792138387 cites W2021779926 @default.
• W1792138387 cites W2022116599 @default.
• W1792138387 cites W2022429307 @default.
• W1792138387 cites W2024835252 @default.
• W1792138387 cites W2028092699 @default.
• W1792138387 cites W2038879439 @default.
• W1792138387 cites W2039757972 @default.
• W1792138387 cites W2039853192 @default.
• W1792138387 cites W2040959525 @default.
• W1792138387 cites W2046876844 @default.
• W1792138387 cites W2055525901 @default.
• W1792138387 cites W2058993504 @default.
• W1792138387 cites W2061984547 @default.
• W1792138387 cites W2063588399 @default.
• W1792138387 cites W2073281086 @default.
• W1792138387 cites W2077284434 @default.
• W1792138387 cites W2077510553 @default.
• W1792138387 cites W2082340361 @default.
• W1792138387 cites W2084928674 @default.
• W1792138387 cites W2104874173 @default.
• W1792138387 cites W2121792022 @default.
• W1792138387 cites W2129711319 @default.
• W1792138387 cites W2133336521 @default.
• W1792138387 cites W2140115103 @default.
• W1792138387 cites W2142113116 @default.
• W1792138387 cites W2153549293 @default.
• W1792138387 cites W2161723357 @default.
• W1792138387 cites W2167229576 @default.
• W1792138387 cites W21845876 @default.
• W1792138387 cites W2230483323 @default.
• W1792138387 cites W2396033089 @default.
• W1792138387 doi "https://doi.org/10.1186/1471-2172-5-21" @default.
• W1792138387 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/524171" @default.
• W1792138387 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15383153" @default.
• W1792138387 hasPublicationYear "2004" @default.
• W1792138387 type Work @default.
• W1792138387 sameAs 1792138387 @default.
• W1792138387 citedByCount "7" @default.
• W1792138387 countsByYear W17921383872012 @default.
• W1792138387 countsByYear W17921383872015 @default.
• W1792138387 countsByYear W17921383872018 @default.
• W1792138387 countsByYear W17921383872021 @default.
• W1792138387 crossrefType "journal-article" @default.
• W1792138387 hasAuthorship W1792138387A5007447330 @default.
• W1792138387 hasAuthorship W1792138387A5027094360 @default.
• W1792138387 hasAuthorship W1792138387A5037122776 @default.
• W1792138387 hasAuthorship W1792138387A5045833196 @default.
• W1792138387 hasAuthorship W1792138387A5051896063 @default.
• W1792138387 hasAuthorship W1792138387A5052988199 @default.
• W1792138387 hasAuthorship W1792138387A5066772857 @default.
• W1792138387 hasAuthorship W1792138387A5088765980 @default.
• W1792138387 hasBestOaLocation W17921383871 @default.
• W1792138387 hasConcept C1009742 @default.
• W1792138387 hasConcept C104317684 @default.
• W1792138387 hasConcept C153911025 @default.
• W1792138387 hasConcept C159654299 @default.

• next