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- W179217333 abstract "The efficacy of neuroleptic antipsychotic drugs has been well demonstrated and neuroleptics are the standard treatment of acute psychosis. However, important aspects of neuroleptic treatment, including course of response, optimal doses, and mechanism of action, remain poorly studied or controversial. Placebo-controlled studies of the onset of the response of acute psychosis to neuroleptics are few and yield conflicting results. Studies of the relationship of doses and blood levels to the therapeutic effects of neuroleptics suggest that the optimal range of doses and levels is narrow and that commonly used doses are too high. Finally, studies of the mechanism of action of neuroleptics suggest that the dopamine hypothesis is based on unsupported assumptions concerning drug effects, drug distribution, and effective doses of drug. Alternative hypotheses, that the antipsychotic effects of the neuroleptics are mediated, at least in part, through α1-adrenergic or serotonin 5-HT2 receptor antagonism, are reviewed. The evidence regarding these issues and controversies is discussed, and specific approaches to increase our understanding and enhance our use of the neuroleptics are suggested.KeywordsAntipsychotic DrugTardive DyskinesiaNeuroleptic DrugAcute PsychosisNeuroleptic TreatmentThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves." @default.
- W179217333 created "2016-06-24" @default.
- W179217333 creator A5091796070 @default.
- W179217333 date "1988-01-01" @default.
- W179217333 modified "2023-09-27" @default.
- W179217333 title "Neuroleptic Drugs in the Treatment of Acute Psychosis: How Much Do We Really Know?" @default.
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- W179217333 doi "https://doi.org/10.1007/978-3-642-73280-5_5" @default.
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- W179217333 hasPublicationYear "1988" @default.
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