Matches in SemOpenAlex for { <https://semopenalex.org/work/W179281402> ?p ?o ?g. }
- W179281402 endingPage "819" @default.
- W179281402 startingPage "807" @default.
- W179281402 abstract "Several data implicate the immune system in bone lost after estrogen deficiency, however, some of the effects on the immune system of estrogen deficiency or of estrogen receptor (ER) modulation are not well established. In this study, the effect of ER agonists on the immune system in ovariectomized mice is analyzed. Mice were ovariectomized and were administered 17β-estradiol (E2), raloxifene (RAL) or genistein (GEN). The effect of a 4-week treatment on bone turnover and on several parameters that reflect the status of the immune system was studied. Results show that ovariectomy provoked both uterine atrophy and thymic hypertrophy. Although RAL corrected thymic hypertrophy, only E2 corrected both. Ovariectomized mice showed increased levels of serum calcium and cathepsin K gene expression and decreased levels of serum alkaline phosphatase (ALP) activity, which suggests that there is a persistent alteration in bone metabolism. Moreover, ovariectomy increased B-cells and CD25+ cells, and decreased the percentages of T-cells and Cbfa1 gene expression in bone marrow (BM). All ER agonists corrected, although to different degrees, changes induced by the ovariectomy. Furthermore, results showed that it is essential to adjust ER agonist doses to avoid immunosuppression, since all ER agonists decreased BM T-cell levels." @default.
- W179281402 created "2016-06-24" @default.
- W179281402 creator A5010654479 @default.
- W179281402 creator A5016066626 @default.
- W179281402 creator A5061035710 @default.
- W179281402 creator A5066123219 @default.
- W179281402 creator A5070181125 @default.
- W179281402 creator A5080122972 @default.
- W179281402 creator A5082802728 @default.
- W179281402 date "2006-10-01" @default.
- W179281402 modified "2023-09-26" @default.
- W179281402 title "Estrogen Receptor Agonists and Immune System in Ovariectomized Mice" @default.
- W179281402 cites W1494403297 @default.
- W179281402 cites W1538221989 @default.
- W179281402 cites W1593442063 @default.
- W179281402 cites W1597881730 @default.
- W179281402 cites W1677043489 @default.
- W179281402 cites W1908178761 @default.
- W179281402 cites W1974660371 @default.
- W179281402 cites W1985542200 @default.
- W179281402 cites W1988496527 @default.
- W179281402 cites W1989048614 @default.
- W179281402 cites W1993183055 @default.
- W179281402 cites W1995628991 @default.
- W179281402 cites W1995946399 @default.
- W179281402 cites W1996832214 @default.
- W179281402 cites W1997883187 @default.
- W179281402 cites W1998316806 @default.
- W179281402 cites W2001241660 @default.
- W179281402 cites W2008039212 @default.
- W179281402 cites W2021427813 @default.
- W179281402 cites W2022763583 @default.
- W179281402 cites W2028694464 @default.
- W179281402 cites W2041603571 @default.
- W179281402 cites W2048299560 @default.
- W179281402 cites W2072231974 @default.
- W179281402 cites W2078875360 @default.
- W179281402 cites W2082678147 @default.
- W179281402 cites W2090491560 @default.
- W179281402 cites W2092099741 @default.
- W179281402 cites W2092505499 @default.
- W179281402 cites W2098359902 @default.
- W179281402 cites W2127355714 @default.
- W179281402 cites W2127546602 @default.
- W179281402 cites W2133281510 @default.
- W179281402 cites W2135299810 @default.
- W179281402 cites W2139845711 @default.
- W179281402 cites W2158856171 @default.
- W179281402 cites W2172185687 @default.
- W179281402 cites W4254761345 @default.
- W179281402 doi "https://doi.org/10.1177/039463200601900410" @default.
- W179281402 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17166402" @default.
- W179281402 hasPublicationYear "2006" @default.
- W179281402 type Work @default.
- W179281402 sameAs 179281402 @default.
- W179281402 citedByCount "20" @default.
- W179281402 countsByYear W1792814022012 @default.
- W179281402 countsByYear W1792814022014 @default.
- W179281402 countsByYear W1792814022017 @default.
- W179281402 countsByYear W1792814022019 @default.
- W179281402 crossrefType "journal-article" @default.
- W179281402 hasAuthorship W179281402A5010654479 @default.
- W179281402 hasAuthorship W179281402A5016066626 @default.
- W179281402 hasAuthorship W179281402A5061035710 @default.
- W179281402 hasAuthorship W179281402A5066123219 @default.
- W179281402 hasAuthorship W179281402A5070181125 @default.
- W179281402 hasAuthorship W179281402A5080122972 @default.
- W179281402 hasAuthorship W179281402A5082802728 @default.
- W179281402 hasConcept C121608353 @default.
- W179281402 hasConcept C126322002 @default.
- W179281402 hasConcept C134018914 @default.
- W179281402 hasConcept C170033053 @default.
- W179281402 hasConcept C170493617 @default.
- W179281402 hasConcept C185592680 @default.
- W179281402 hasConcept C203014093 @default.
- W179281402 hasConcept C2777164284 @default.
- W179281402 hasConcept C2778938600 @default.
- W179281402 hasConcept C2779889926 @default.
- W179281402 hasConcept C530470458 @default.
- W179281402 hasConcept C71924100 @default.
- W179281402 hasConcept C8264082 @default.
- W179281402 hasConcept C84606932 @default.
- W179281402 hasConcept C86803240 @default.
- W179281402 hasConcept C8891405 @default.
- W179281402 hasConceptScore W179281402C121608353 @default.
- W179281402 hasConceptScore W179281402C126322002 @default.
- W179281402 hasConceptScore W179281402C134018914 @default.
- W179281402 hasConceptScore W179281402C170033053 @default.
- W179281402 hasConceptScore W179281402C170493617 @default.
- W179281402 hasConceptScore W179281402C185592680 @default.
- W179281402 hasConceptScore W179281402C203014093 @default.
- W179281402 hasConceptScore W179281402C2777164284 @default.
- W179281402 hasConceptScore W179281402C2778938600 @default.
- W179281402 hasConceptScore W179281402C2779889926 @default.
- W179281402 hasConceptScore W179281402C530470458 @default.
- W179281402 hasConceptScore W179281402C71924100 @default.
- W179281402 hasConceptScore W179281402C8264082 @default.
- W179281402 hasConceptScore W179281402C84606932 @default.