FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1793068886> ?p ?o ?g. }

• W1793068886 endingPage "6308" @default.
• W1793068886 startingPage "6300" @default.
• W1793068886 abstract "Abstract Lung infections represent a tremendous disease burden and a leading cause of acute lung injury. STAT3 signaling is essential for controlling lung injury during pneumonia. We previously identified LIF as a prominent STAT3-activating cytokine expressed in the airspaces of pneumonic lungs, but its physiological significance in this setting has never been explored. To do so, Escherichia coli was intratracheally instilled into C57BL/6 mice in the presence of neutralizing anti-LIF IgG or control IgG. Anti-LIF completely eliminated lung LIF detection and markedly exacerbated lung injury compared with control mice as evidenced by airspace albumin content, lung liquid accumulation, and histological analysis. Although lung bacteriology was equivalent between groups, bacteremia was more prevalent with anti-LIF treatment, suggestive of compromised barrier function rather than impaired antibacterial defense as the cause of dissemination. Inflammatory cytokine expression was also exaggerated in anti-LIF–treated lungs, albeit after injury had ensued. Interestingly, alveolar neutrophil recruitment was modestly but significantly reduced compared with control mice despite elevated cytokine levels, indicating that inflammatory injury was not a consequence of excessive neutrophilic alveolitis. Lastly, the lung transcriptome was dramatically remodeled during pneumonia, but far more so following LIF neutralization, with gene changes implicating cell death and epithelial homeostasis among other processes relevant to tissue injury. From these findings, we conclude that endogenous LIF facilitates tissue protection during pneumonia. The LIF–STAT3 axis is identified in this study as a critical determinant of lung injury with clinical implications for pneumonia patients." @default.
• W1793068886 created "2016-06-24" @default.
• W1793068886 creator A5002939091 @default.
• W1793068886 creator A5003564006 @default.
• W1793068886 creator A5064859743 @default.
• W1793068886 creator A5067130815 @default.
• W1793068886 creator A5076243223 @default.
• W1793068886 creator A5082886218 @default.
• W1793068886 date "2012-06-15" @default.
• W1793068886 modified "2023-10-10" @default.
• W1793068886 title "Leukemia Inhibitory Factor Signaling Is Required for Lung Protection during Pneumonia" @default.
• W1793068886 cites W129883404 @default.
• W1793068886 cites W1534580282 @default.
• W1793068886 cites W1549542172 @default.
• W1793068886 cites W1593914605 @default.
• W1793068886 cites W1630706121 @default.
• W1793068886 cites W1743901842 @default.
• W1793068886 cites W1941550453 @default.
• W1793068886 cites W1963631663 @default.
• W1793068886 cites W1964052073 @default.
• W1793068886 cites W1973673010 @default.
• W1793068886 cites W1974267497 @default.
• W1793068886 cites W1977092670 @default.
• W1793068886 cites W1977789231 @default.
• W1793068886 cites W1980790915 @default.
• W1793068886 cites W1989250397 @default.
• W1793068886 cites W1992977298 @default.
• W1793068886 cites W1994885986 @default.
• W1793068886 cites W1995559307 @default.
• W1793068886 cites W2004877269 @default.
• W1793068886 cites W2005060346 @default.
• W1793068886 cites W2005332192 @default.
• W1793068886 cites W2018855387 @default.
• W1793068886 cites W2024085541 @default.
• W1793068886 cites W2028982367 @default.
• W1793068886 cites W2029548823 @default.
• W1793068886 cites W2034722578 @default.
• W1793068886 cites W2034987992 @default.
• W1793068886 cites W2036326229 @default.
• W1793068886 cites W2039739211 @default.
• W1793068886 cites W2040000631 @default.
• W1793068886 cites W2043483036 @default.
• W1793068886 cites W2051377548 @default.
• W1793068886 cites W2053298425 @default.
• W1793068886 cites W2056212017 @default.
• W1793068886 cites W2061070237 @default.
• W1793068886 cites W2066656234 @default.
• W1793068886 cites W2070942210 @default.
• W1793068886 cites W2080311121 @default.
• W1793068886 cites W2081447262 @default.
• W1793068886 cites W2086840459 @default.
• W1793068886 cites W2105912583 @default.
• W1793068886 cites W2113198849 @default.
• W1793068886 cites W2114176892 @default.
• W1793068886 cites W2114249751 @default.
• W1793068886 cites W2114570412 @default.
• W1793068886 cites W2117679551 @default.
• W1793068886 cites W2118253052 @default.
• W1793068886 cites W2118480748 @default.
• W1793068886 cites W2119100690 @default.
• W1793068886 cites W2127592597 @default.
• W1793068886 cites W2128527872 @default.
• W1793068886 cites W2131626429 @default.
• W1793068886 cites W2135474516 @default.
• W1793068886 cites W2135827569 @default.
• W1793068886 cites W2142296051 @default.
• W1793068886 cites W2151630650 @default.
• W1793068886 cites W2155111689 @default.
• W1793068886 cites W2159545888 @default.
• W1793068886 cites W2159548259 @default.
• W1793068886 cites W2159763561 @default.
• W1793068886 cites W2160878167 @default.
• W1793068886 cites W2160883911 @default.
• W1793068886 cites W2165133447 @default.
• W1793068886 cites W2170237721 @default.
• W1793068886 cites W2172094131 @default.
• W1793068886 cites W95315447 @default.
• W1793068886 doi "https://doi.org/10.4049/jimmunol.1200256" @default.
• W1793068886 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3370070" @default.
• W1793068886 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22581855" @default.
• W1793068886 hasPublicationYear "2012" @default.
• W1793068886 type Work @default.
• W1793068886 sameAs 1793068886 @default.
• W1793068886 citedByCount "60" @default.
• W1793068886 countsByYear W17930688862012 @default.
• W1793068886 countsByYear W17930688862013 @default.
• W1793068886 countsByYear W17930688862014 @default.
• W1793068886 countsByYear W17930688862015 @default.
• W1793068886 countsByYear W17930688862016 @default.
• W1793068886 countsByYear W17930688862017 @default.
• W1793068886 countsByYear W17930688862018 @default.
• W1793068886 countsByYear W17930688862019 @default.
• W1793068886 countsByYear W17930688862020 @default.
• W1793068886 countsByYear W17930688862021 @default.
• W1793068886 countsByYear W17930688862022 @default.
• W1793068886 countsByYear W17930688862023 @default.
• W1793068886 crossrefType "journal-article" @default.
• W1793068886 hasAuthorship W1793068886A5002939091 @default.

• next