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• W1793115003 abstract "Abstract Host resistance to the intracellular protozoan Toxoplasma gondii is highly dependent on early IL-12 production by APC. We demonstrate here that both host resistance and T. gondii-induced IL-12 production are dramatically reduced in mice lacking the adaptor molecule MyD88, an important signaling element used by Toll-like receptor (TLR) family members. Infection of MyD88-deficient mice with T. gondii resulted in uncontrolled parasite replication and greatly reduced plasma IL-12 levels. Defective IL-12 responses to T. gondii Ags (soluble tachyzoite Ag (STAg)) were observed in MyD88−/− peritoneal macrophages, neutrophils, and splenic dendritic cells (DC). In contrast, DC from TLR2- or TLR4-deficient animals developed normal IL-12 responses to STAg. In vivo treatment with pertussis toxin abolished the residual IL-12 response displayed by STAg-stimulated DC from MyD88−/− mice. Taken together, these data suggest that the induction of IL-12 by T. gondii depends on a unique mechanism involving both MyD88 and G protein-coupled signaling pathways." @default.
• W1793115003 created "2016-06-24" @default.
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• W1793115003 date "2002-06-15" @default.
• W1793115003 modified "2023-10-10" @default.
• W1793115003 title "Cutting Edge: MyD88 Is Required for Resistance to <i>Toxoplasma gondii</i> Infection and Regulates Parasite-Induced IL-12 Production by Dendritic Cells" @default.
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• W1793115003 doi "https://doi.org/10.4049/jimmunol.168.12.5997" @default.
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