FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1793205621> ?p ?o ?g. }

• W1793205621 endingPage "279" @default.
• W1793205621 startingPage "271" @default.
• W1793205621 abstract "The B6.Sle1.Sle2.Sle3 triple congenic mouse (B6.TC) is a model of lupus coexpressing the three major NZM2410-derived susceptibility loci on a C57BL/6 background. B6.TC mice produce high titers of antinuclear nephrogenic autoantibodies and a highly penetrant glomerulonephritis. Previous studies have shown the Sle1 locus is associated with a reduced number of regulatory T cells (Treg) and that Sle3 results in intrinsic defects of myeloid cells that hyperactivate T cells. In this report, we show that B6.TC dendritic cells (DCs) accumulate in lymphoid organs and present a defective maturation process, in which bone marrow-derived, plasmacytoid, and myeloid DCs express a significantly lower level of CD80, CD86, and MHC class II. B6.TC DCs also induce a higher level of proliferation in CD4(+) T cells than B6 DCs, and B6.TC DCs block the suppressive activity of Treg. B6.TC DCs overproduce IL-6, which is necessary for the blockade of Treg activity, as shown by the effect of anti-IL-6 neutralizing Ab in the suppression assays. The overproduction of IL-6 by DCs and the blockade of Treg activity maps to Sle1, which therefore not only confers a reduced number of Treg but also blocks their ability to regulate autoreactive T cells. Taken together, these results provide a genetic and mechanistic evidence for systemic autoimmunity resulting from an impaired regulatory T cell compartment in both number and function and for Sle1-expressing DCs playing a major role in the latter defect though their production of IL-6." @default.
• W1793205621 created "2016-06-24" @default.
• W1793205621 creator A5002019326 @default.
• W1793205621 creator A5049434542 @default.
• W1793205621 creator A5077433884 @default.
• W1793205621 date "2006-12-19" @default.
• W1793205621 modified "2023-10-12" @default.
• W1793205621 title "IL-6 Produced by Dendritic Cells from Lupus-Prone Mice Inhibits CD4⁺CD25⁺ T Cell Regulatory Functions" @default.
• W1793205621 cites W1480458795 @default.
• W1793205621 cites W1517081568 @default.
• W1793205621 cites W1539168488 @default.
• W1793205621 cites W1547552531 @default.
• W1793205621 cites W1592605841 @default.
• W1793205621 cites W1607833631 @default.
• W1793205621 cites W1650168614 @default.
• W1793205621 cites W1663350071 @default.
• W1793205621 cites W1862089716 @default.
• W1793205621 cites W1932956512 @default.
• W1793205621 cites W1959856035 @default.
• W1793205621 cites W1968959595 @default.
• W1793205621 cites W1975640488 @default.
• W1793205621 cites W1982913914 @default.
• W1793205621 cites W1995928270 @default.
• W1793205621 cites W2001373821 @default.
• W1793205621 cites W2001740313 @default.
• W1793205621 cites W2018412076 @default.
• W1793205621 cites W2024351056 @default.
• W1793205621 cites W2029775066 @default.
• W1793205621 cites W2041303685 @default.
• W1793205621 cites W2051064003 @default.
• W1793205621 cites W2065907531 @default.
• W1793205621 cites W2069582132 @default.
• W1793205621 cites W2071969437 @default.
• W1793205621 cites W2075036714 @default.
• W1793205621 cites W2087976968 @default.
• W1793205621 cites W2092991947 @default.
• W1793205621 cites W2106187671 @default.
• W1793205621 cites W2113523651 @default.
• W1793205621 cites W2117576441 @default.
• W1793205621 cites W2124975442 @default.
• W1793205621 cites W2125921975 @default.
• W1793205621 cites W2127043344 @default.
• W1793205621 cites W2136394997 @default.
• W1793205621 cites W2136600416 @default.
• W1793205621 cites W2149965740 @default.
• W1793205621 cites W2154628725 @default.
• W1793205621 cites W2154683465 @default.
• W1793205621 cites W2157040330 @default.
• W1793205621 cites W2158188150 @default.
• W1793205621 cites W2158538721 @default.
• W1793205621 cites W4250078554 @default.
• W1793205621 cites W54413410 @default.
• W1793205621 doi "https://doi.org/10.4049/jimmunol.178.1.271" @default.
• W1793205621 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17182564" @default.
• W1793205621 hasPublicationYear "2006" @default.
• W1793205621 type Work @default.
• W1793205621 sameAs 1793205621 @default.
• W1793205621 citedByCount "177" @default.
• W1793205621 countsByYear W17932056212012 @default.
• W1793205621 countsByYear W17932056212013 @default.
• W1793205621 countsByYear W17932056212014 @default.
• W1793205621 countsByYear W17932056212015 @default.
• W1793205621 countsByYear W17932056212016 @default.
• W1793205621 countsByYear W17932056212017 @default.
• W1793205621 countsByYear W17932056212018 @default.
• W1793205621 countsByYear W17932056212019 @default.
• W1793205621 countsByYear W17932056212020 @default.
• W1793205621 countsByYear W17932056212021 @default.
• W1793205621 countsByYear W17932056212022 @default.
• W1793205621 countsByYear W17932056212023 @default.
• W1793205621 crossrefType "journal-article" @default.
• W1793205621 hasAuthorship W1793205621A5002019326 @default.
• W1793205621 hasAuthorship W1793205621A5049434542 @default.
• W1793205621 hasAuthorship W1793205621A5077433884 @default.
• W1793205621 hasBestOaLocation W17932056211 @default.
• W1793205621 hasConcept C104317684 @default.
• W1793205621 hasConcept C127716648 @default.
• W1793205621 hasConcept C154317977 @default.
• W1793205621 hasConcept C202751555 @default.
• W1793205621 hasConcept C203014093 @default.
• W1793205621 hasConcept C2776090121 @default.
• W1793205621 hasConcept C2778297628 @default.
• W1793205621 hasConcept C2779282312 @default.
• W1793205621 hasConcept C2779919695 @default.
• W1793205621 hasConcept C2780130043 @default.
• W1793205621 hasConcept C2781101188 @default.
• W1793205621 hasConcept C39347974 @default.
• W1793205621 hasConcept C54355233 @default.
• W1793205621 hasConcept C84951073 @default.
• W1793205621 hasConcept C86803240 @default.
• W1793205621 hasConcept C8891405 @default.
• W1793205621 hasConcept C95444343 @default.
• W1793205621 hasConceptScore W1793205621C104317684 @default.
• W1793205621 hasConceptScore W1793205621C127716648 @default.
• W1793205621 hasConceptScore W1793205621C154317977 @default.
• W1793205621 hasConceptScore W1793205621C202751555 @default.
• W1793205621 hasConceptScore W1793205621C203014093 @default.
• W1793205621 hasConceptScore W1793205621C2776090121 @default.

• next