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- W179352461 endingPage "617" @default.
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- W179352461 abstract "The PDZ domain–containing proteins, such as PSD-95 and GRIP, have been suggested to be involved in the targeting of glutamate receptors, a process that plays a critical role in the efficiency of synaptic transmission and plasticity. To address the molecular mechanisms underlying AMPA receptor synaptic localization, we have identified several GRIP-associated proteins (GRASPs) that bind to distinct PDZ domains within GRIP. GRASP-1 is a neuronal rasGEF associated with GRIP and AMPA receptors in vivo. Overexpression of GRASP-1 in cultured neurons specifically reduced the synaptic targeting of AMPA receptors. In addition, the subcellular distribution of both AMPA receptors and GRASP-1 was rapidly regulated by the activation of NMDA receptors. These results suggest that GRASP-1 may regulate neuronal ras signaling and contribute to the regulation of AMPA receptor distribution by NMDA receptor activity." @default.
- W179352461 created "2016-06-24" @default.
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- W179352461 creator A5079294349 @default.
- W179352461 date "2000-06-01" @default.
- W179352461 modified "2023-10-06" @default.
- W179352461 title "GRASP-1" @default.
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- W179352461 doi "https://doi.org/10.1016/s0896-6273(00)81198-8" @default.
- W179352461 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10896157" @default.
- W179352461 hasPublicationYear "2000" @default.
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