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• W1793561008 abstract "Combination therapy in cholesterol reduction: focus on ezetimibe and statins Liliana Grigore1, Giuseppe Danilo Norata1,2, Alberico L Catapano1,21Department of Pharmacological Sciences, University of Milan, Milan, Italy; 2Center for the Study of Atherosclerosis, Bassini Hospital, Cinisello B, ItalyAbstract: Although widely used in lipid lowering therapy, HMG CoA reductase inhibitors (even when administered at high doses) are frequently insufficient to achieve guideline-recommended LDL-C goals for many patients with hypercholesterolemia in everyday clinical practice. Many patients do not achieve LDL-C goal on the initial dose of statin and the majority of these patients does not reach their goal after 6 months. As a consequence, a wide therapeutic gap exists between target LDL-C levels and those typically achieved in clinical practice. A recent and more effective therapeutic hypocholesterolemic strategy is to treat the two main sources of cholesterol simultaneously (production of cholesterol, mainly in the liver, and absorption of cholesterol in the intestine) with a complementary mechanism of action, by co-administering ezetimibe, a novel agent inhibiting cholesterol absorption, with a statin, which inhibits cholesterol production in the liver. Ezetimibe can be effectively and safely co-administered with any dose of any statin and, compared with the single inhibition of cholesterol production, afforded by statins alone, provides consistently greater reductions in LDL-C through dual inhibition of both cholesterol production and absorption. We summarize the pivotal role of both the liver and intestine in the overall balance of cholesterol in the body and describe the clinical impact and relevance of using ezetimibe either alone or co-administered with statins in controlling elevated levels of plasma LDL cholesterol.Keywords: hypercholesterolemia, cholesterol absorption, cholesterol biosynthesis, ezetimibe, HMG CoA reductase inhibitors, LDL-C" @default.
• W1793561008 created "2016-06-24" @default.
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• W1793561008 date "2008-04-01" @default.
• W1793561008 modified "2023-10-14" @default.
• W1793561008 title "Combination therapy in cholesterol reduction: focus on ezetimibe and statins" @default.
• W1793561008 cites W1922625321 @default.
• W1793561008 cites W1967383774 @default.
• W1793561008 cites W1969721624 @default.
• W1793561008 cites W1977126756 @default.
• W1793561008 cites W1981798840 @default.
• W1793561008 cites W1982715024 @default.
• W1793561008 cites W1983422922 @default.
• W1793561008 cites W1984217297 @default.
• W1793561008 cites W1986260182 @default.
• W1793561008 cites W1987507883 @default.
• W1793561008 cites W1990756353 @default.
• W1793561008 cites W1992084132 @default.
• W1793561008 cites W1995116750 @default.
• W1793561008 cites W2001041427 @default.
• W1793561008 cites W2012533363 @default.
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• W1793561008 cites W2054688528 @default.
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• W1793561008 doi "https://doi.org/10.2147/vhrm.s1204" @default.
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