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- W1793691728 endingPage "2340" @default.
- W1793691728 startingPage "2329" @default.
- W1793691728 abstract "Abstract Almost all drugs approved for use in humans possess potentially beneficial ‘off‐target’ effects in addition to their principal activity. In some cases this has allowed for the relatively rapid repurposing of drugs for other indications. In this review we focus on the potential for re‐purposing FTY 720 (also known as fingolimod, Gilenya ™ ), an immunomodulatory drug recently approved for the treatment of multiple sclerosis ( MS ). The therapeutic benefit of FTY 720 in MS is largely attributed to the immunosuppressive effects that result from its modulation of sphingosine 1‐phosphate receptor signalling. However, this drug has also been shown to inhibit other cancer‐associated signal transduction pathways in part because of its structural similarity to sphingosine, and consequently shows efficacy as an anti‐cancer agent both in vitro and in vivo . Here, we review the effects of FTY 720 on signal transduction pathways and cancer‐related cellular processes, and discuss its potential use as an anti‐cancer drug." @default.
- W1793691728 created "2016-06-24" @default.
- W1793691728 creator A5014005227 @default.
- W1793691728 creator A5017842948 @default.
- W1793691728 creator A5060605768 @default.
- W1793691728 creator A5088625486 @default.
- W1793691728 date "2015-07-14" @default.
- W1793691728 modified "2023-10-03" @default.
- W1793691728 title "The antineoplastic properties of <scp>FTY</scp> 720: evidence for the repurposing of fingolimod" @default.
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