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• W1793910073 abstract "In the lungs, parasympathetic nerves provide the dominant control of airway smooth muscle with release of acetylcholine onto M3 muscarinic receptors. Treatment of airway disease with anticholinergic drugs that block muscarinic receptors began over 2000 years ago. Pharmacologic data all indicated that antimuscarinic drugs should be highly effective in asthma but clinical results were mixed. Thus, with the discovery of effective β‐adrenergic receptor agonists the use of muscarinic antagonists declined. Lack of effectiveness of muscarinic antagonists is due to a variety of factors including unwanted side effects (ranging from dry mouth to coma) and the discovery of additional muscarinic receptor subtypes in the lungs with sometimes competing effects. Perhaps the most important problem is ineffective dosing due to poorly understood differences between routes of administration and no effective way of testing whether antagonists block receptors stimulated physiologically by acetylcholine. Newer muscarinic receptor antagonists are being developed that address the problems of side effects and receptor selectivity that appear to be quite promising in the treatment of asthma and chronic obstructive pulmonary disease. LINKED ARTICLES This article is part of a themed issue on Respiratory Pharmacology. To view the other articles in this issue visit http://dx.doi.org/10.1111/bph.2011.163.issue‐1" @default.
• W1793910073 created "2016-06-24" @default.
• W1793910073 creator A5062581638 @default.
• W1793910073 creator A5090522151 @default.
• W1793910073 date "2011-04-06" @default.
• W1793910073 modified "2023-10-18" @default.
• W1793910073 title "Muscarinic receptor antagonists, from folklore to pharmacology; finding drugs that actually work in asthma and COPD" @default.
• W1793910073 cites W1531230527 @default.
• W1793910073 cites W1587498640 @default.
• W1793910073 cites W1691176284 @default.
• W1793910073 cites W1769215519 @default.
• W1793910073 cites W1862886500 @default.
• W1793910073 cites W1961645094 @default.
• W1793910073 cites W1964502233 @default.
• W1793910073 cites W1965728531 @default.
• W1793910073 cites W1967754504 @default.
• W1793910073 cites W1969413415 @default.
• W1793910073 cites W1972368606 @default.
• W1793910073 cites W1978222663 @default.
• W1793910073 cites W1978457536 @default.
• W1793910073 cites W1987261161 @default.
• W1793910073 cites W1987779503 @default.
• W1793910073 cites W1987787401 @default.
• W1793910073 cites W1992410603 @default.
• W1793910073 cites W1993949793 @default.
• W1793910073 cites W1997035092 @default.
• W1793910073 cites W1998024345 @default.
• W1793910073 cites W1999800943 @default.
• W1793910073 cites W2000532155 @default.
• W1793910073 cites W2008872290 @default.
• W1793910073 cites W2010279385 @default.
• W1793910073 cites W2011296887 @default.
• W1793910073 cites W2011384746 @default.
• W1793910073 cites W2017694734 @default.
• W1793910073 cites W2026350647 @default.
• W1793910073 cites W2030732178 @default.
• W1793910073 cites W2030835797 @default.
• W1793910073 cites W2031990050 @default.
• W1793910073 cites W2040757185 @default.
• W1793910073 cites W2050210781 @default.
• W1793910073 cites W2050657361 @default.
• W1793910073 cites W2055707452 @default.
• W1793910073 cites W2056765555 @default.
• W1793910073 cites W2059005844 @default.
• W1793910073 cites W2062131199 @default.
• W1793910073 cites W2067551561 @default.
• W1793910073 cites W2067862917 @default.
• W1793910073 cites W2071859094 @default.
• W1793910073 cites W2073599498 @default.
• W1793910073 cites W2077081008 @default.
• W1793910073 cites W2081681374 @default.
• W1793910073 cites W2083208218 @default.
• W1793910073 cites W2084496156 @default.
• W1793910073 cites W2084613369 @default.
• W1793910073 cites W2084700008 @default.
• W1793910073 cites W2087088084 @default.
• W1793910073 cites W2101593525 @default.
• W1793910073 cites W2107045802 @default.
• W1793910073 cites W2110113091 @default.
• W1793910073 cites W2110689875 @default.
• W1793910073 cites W2112360320 @default.
• W1793910073 cites W2121653483 @default.
• W1793910073 cites W2125895372 @default.
• W1793910073 cites W2126325768 @default.
• W1793910073 cites W2137636579 @default.
• W1793910073 cites W2141034778 @default.
• W1793910073 cites W2141391560 @default.
• W1793910073 cites W2141539821 @default.
• W1793910073 cites W2142158607 @default.
• W1793910073 cites W2149199480 @default.
• W1793910073 cites W2157690305 @default.
• W1793910073 cites W2158796327 @default.
• W1793910073 cites W2160346225 @default.
• W1793910073 cites W2167955309 @default.
• W1793910073 cites W2168750771 @default.
• W1793910073 cites W2169278962 @default.
• W1793910073 cites W2171733019 @default.
• W1793910073 cites W2179089431 @default.
• W1793910073 cites W2189727296 @default.
• W1793910073 cites W2236731712 @default.
• W1793910073 cites W2254170473 @default.
• W1793910073 cites W2342672200 @default.
• W1793910073 cites W2343065248 @default.
• W1793910073 cites W3022961933 @default.
• W1793910073 cites W3176509832 @default.
• W1793910073 cites W4211263216 @default.
• W1793910073 cites W4231754036 @default.
• W1793910073 cites W4235755338 @default.
• W1793910073 cites W4237805405 @default.
• W1793910073 cites W4239080780 @default.
• W1793910073 cites W4243709722 @default.
• W1793910073 cites W4312444005 @default.
• W1793910073 cites W4320288047 @default.
• W1793910073 doi "https://doi.org/10.1111/j.1476-5381.2010.01190.x" @default.
• W1793910073 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3085867" @default.
• W1793910073 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21198547" @default.
• W1793910073 hasPublicationYear "2011" @default.
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