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- W1793916809 endingPage "171" @default.
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- W1793916809 abstract "This chapter reviews the general functions of immediate early genes (IEGs) in the nervous system and, in particular, examines their potential roles in adaptive gene expression following neuronal trauma. IEGs become rapidly activated when a eukaryotic cell is exposed to a stimulus such as serum, growth hormones or ion channel activators. These genes are involved in the regulation of normal growth, mitosis, and differentiation of cells and encode for secretory proteins, enzymes, membrane-bound receptors and for transcription factors. The chapter focuses on the inducible transcription factor proteins of the jun, fos, and krox families. The transcription promoting capability of Fos proteins becomes significant only after association with other nuclear proteins such as cJun or its related proteins, JunB, and JunD. The time courses of Jun and Krox-24 expression show clear differences between the axotomized neuronal populations and the chapter hypothesizes that the strength and persistence of IEG expression reflects the endogenous neuronal propensity for regeneration, irrespective of the inhibitory microenvironment." @default.
- W1793916809 created "2016-06-24" @default.
- W1793916809 creator A5013363726 @default.
- W1793916809 creator A5047805663 @default.
- W1793916809 date "1994-01-01" @default.
- W1793916809 modified "2023-10-18" @default.
- W1793916809 title "Chapter 15 Expression of c-Jun and JunD transcription factors represent specific changes in neuronal gene expression following axotomy" @default.
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