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- W179431542 abstract "In D. discoideum, RNA and protein syntheses were not restricted to any particular stage of morphogenesis but continued throughout. However, the contents of RNA and protein decreased progressively during development. Sucrose density-gradient analysis showed that polysomes varied in size throughout development and that the amounts of polysomes decreased during development. The sedimentation patterns of rapidly labeled RNA in polysomes differed significantly at three different stages of development. Actinomycin D prevented development of the amoebae and incorporation of 3H-uridine into RNA of whole cells when added at an early stage of morphogenesis. It did not affect incorporation of 14C-amino acids into protein. Cycloheximide inhibited overall morphogenesis and 14C-amino acid incorporation at almost all stages of development. The relationship between RNA and protein syntheses during morphogenesis is discussed." @default.
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- W179431542 date "1970-12-01" @default.
- W179431542 modified "2023-10-17" @default.
- W179431542 title "Effects of actinomycin D and cycloheximide on morphogenesis and syntheses of RNA and protein in the cellular slime mold," @default.
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- W179431542 doi "https://doi.org/10.1016/0014-4827(70)90219-3" @default.
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