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• W1794328125 abstract "Objective: To assess the ability of a silver lipidocolloid contact layer to promote the healing process of venous leg ulcers (VLUs) presenting inflammatory signs, suggesting a heavy bacteria colonisation, and then delayed healing, in comparison with the same wound dressing not impregnated with silver salts. Method: This was an open-labelled, randomised, controlled trial. VLU presenting at least 3 out of 5 clinical signs suggesting heavy bacterial colonisation were recruited. Patients were treated with contact-layer silver-dressing (ClS; Urgotul Silver [URGO Laboratories]) or contact-layer dressing (Cl; Urgotul [URGO laboratories]) for 4 weeks, then all treated ulcers were treated with CL for 4 additional weeks. Wound evaluation and area measurements were conducted weekly, during the first 4 weeks, and then at weeks 6 and 8. Main efficacy criterion was absolute wound area decrease (AD) at week 4 and week 8. Results: Patients (n=102) were randomised and treated. ulcers were present for nearly 11 months on average; 65% were recurrent and mean area was 20.0 ± 17.8cm 2 . almost 80% of the treated VLU were stagnating/aggravating with their previous treatment. by week 4, mean surface area decreased by 6.5 ± 13.4cm 2 (median: 4.2cm 2 ) and 1.3 ± 9.0cm 2 (median: 1.1cm 2 ) in ClS and CL groups, respectively (p=0.023). at week 8, median decrease was 5.9cm 2 vs 0.8cm 2 (p=0.002), with a wound percentage decrease of 48% and 5.6% (p=0.036). Median closure rate was 0.145cm 2 /day vs 0.044cm 2 /day (p=0.009) at week 4 and remained higher in the ClS group up to week 8, even after switching to CL dressing in these patients (p=0.001). odds ratio (multinomial logistic regression) of the chance to reach a ≥40% wound area reduction was 2.7 (95%CI: 1.1;6.7, p=0.038) for silver-treated ulcers. Dressing tolerance was good in both groups. Conclusion: a 4-week treatment with silver-releasing lipidocolloid contact layer promotes a sustained increase of closure rate of venous leg ulcers presenting inflammatory signs, suggesting a high bacterial load. Declaration of interest: This study was funded by a grant from URGO laboratories. Dr Meaume and Dr Lazareth have served as paid speakers for URGO Laboratories. Dr Sauvadet and Dr Bohbot are employees of URGO Laboratories." @default.
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• W1794328125 date "2012-02-01" @default.
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• W1794328125 title "Effcacy of a silver lipidocolloid dressing on heavily colonised wounds: a republished RCT" @default.
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• W1794328125 doi "https://doi.org/10.12968/jowc.2012.21.2.96" @default.
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