FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1794538072> ?p ?o ?g. }

• W1794538072 endingPage "50" @default.
• W1794538072 startingPage "5745" @default.
• W1794538072 abstract "Ewing's sarcoma family of tumors (ESFTs) affects patients between the ages of 3 and 40 years, with most cases occurring in the second decade of life. These tumors contain a characteristic translocation, t(11;22), that produces a unique fusion protein, EWS/FLI-1. EWS/FLI-1 transforms mouse fibroblasts; this transformation requires intact EWS and FLI-1 domains as well as the insulin-like growth factor-I receptor (IGF-IR). The IGF-IR is a well-described transmembrane tyrosine kinase receptor that modulates transformation, cell growth, and survival. IGF-IR survival signaling is mediated through the downstream activation of phosphoinositide 3-OH kinase (PI 3-K) and Akt. Apoptosis, programmed cell death, progresses from a central death signal to a caspase cascade, including activation of caspase-3. Because the IGF-IR has been shown to play a role in the transformation and growth of ESFTs, we wanted to determine the role of downstream molecules in the cellular response to doxorubicin treatment. Doxorubicin increased caspase-3 activity in two ESFT cell lines, TC-32 and TC-71. Concomitant treatment of the doxorubicin-treated cells with IGF-I reduced caspase-3 activity 8-fold in TC-32 and 4-fold in TC-71. To determine whether PI 3-K has a role in IGF-I-mediated survival in ESFTs, PI 3-K was then inhibited with wortmannin and LY294002. Doxorubicin treatment reduced cell number and enhanced apoptosis in PI 3-K inhibited cells compared with noninhibited cells. Akt, a serine/threonine kinase activated downstream of PI 3-K, was investigated to determine whether its constitutive activation would render ESFT cells more resistant to doxorubicin. A constitutively activated Akt was stably transfected into ESFT and those cells with high levels of expression demonstrated increased resistance to doxorubicin-induced caspase-3 activation. These results indicate that ESFT cell lines use an IGF-IR initiated signaling pathway through PI 3-K and Akt for survival when treated with doxorubicin." @default.
• W1794538072 created "2016-06-24" @default.
• W1794538072 creator A5060004934 @default.
• W1794538072 creator A5069392455 @default.
• W1794538072 creator A5077669771 @default.
• W1794538072 creator A5083229382 @default.
• W1794538072 date "1999-11-15" @default.
• W1794538072 modified "2023-09-27" @default.
• W1794538072 title "Phosphoinositide 3-hydroxide kinase blockade enhances apoptosis in the Ewing's sarcoma family of tumors." @default.
• W1794538072 cites W1488956616 @default.
• W1794538072 cites W1600831499 @default.
• W1794538072 cites W1606050714 @default.
• W1794538072 cites W1789215739 @default.
• W1794538072 cites W192608075 @default.
• W1794538072 cites W1954313480 @default.
• W1794538072 cites W1964171663 @default.
• W1794538072 cites W1973837499 @default.
• W1794538072 cites W1980935526 @default.
• W1794538072 cites W1996465555 @default.
• W1794538072 cites W2000664807 @default.
• W1794538072 cites W2018001209 @default.
• W1794538072 cites W2020636054 @default.
• W1794538072 cites W2024306318 @default.
• W1794538072 cites W2030573603 @default.
• W1794538072 cites W2032847000 @default.
• W1794538072 cites W2033801757 @default.
• W1794538072 cites W2035147500 @default.
• W1794538072 cites W2048121649 @default.
• W1794538072 cites W2054711858 @default.
• W1794538072 cites W2058759427 @default.
• W1794538072 cites W2061054148 @default.
• W1794538072 cites W2064059449 @default.
• W1794538072 cites W2069351898 @default.
• W1794538072 cites W2077321849 @default.
• W1794538072 cites W2090566152 @default.
• W1794538072 cites W2093628776 @default.
• W1794538072 cites W2097767970 @default.
• W1794538072 cites W2104135564 @default.
• W1794538072 cites W2117350664 @default.
• W1794538072 cites W2120138780 @default.
• W1794538072 cites W2120662932 @default.
• W1794538072 cites W2141916872 @default.
• W1794538072 cites W2144090287 @default.
• W1794538072 cites W2082844699 @default.
• W1794538072 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10582694" @default.
• W1794538072 hasPublicationYear "1999" @default.
• W1794538072 type Work @default.
• W1794538072 sameAs 1794538072 @default.
• W1794538072 citedByCount "25" @default.
• W1794538072 countsByYear W17945380722013 @default.
• W1794538072 countsByYear W17945380722014 @default.
• W1794538072 countsByYear W17945380722016 @default.
• W1794538072 countsByYear W17945380722018 @default.
• W1794538072 countsByYear W17945380722019 @default.
• W1794538072 countsByYear W17945380722020 @default.
• W1794538072 countsByYear W17945380722022 @default.
• W1794538072 crossrefType "journal-article" @default.
• W1794538072 hasAuthorship W1794538072A5060004934 @default.
• W1794538072 hasAuthorship W1794538072A5069392455 @default.
• W1794538072 hasAuthorship W1794538072A5077669771 @default.
• W1794538072 hasAuthorship W1794538072A5083229382 @default.
• W1794538072 hasConcept C190283241 @default.
• W1794538072 hasConcept C2776912716 @default.
• W1794538072 hasConcept C2778308172 @default.
• W1794538072 hasConcept C2781322055 @default.
• W1794538072 hasConcept C31573885 @default.
• W1794538072 hasConcept C42362537 @default.
• W1794538072 hasConcept C502942594 @default.
• W1794538072 hasConcept C55493867 @default.
• W1794538072 hasConcept C62478195 @default.
• W1794538072 hasConcept C75217442 @default.
• W1794538072 hasConcept C86554907 @default.
• W1794538072 hasConcept C86803240 @default.
• W1794538072 hasConcept C95444343 @default.
• W1794538072 hasConceptScore W1794538072C190283241 @default.
• W1794538072 hasConceptScore W1794538072C2776912716 @default.
• W1794538072 hasConceptScore W1794538072C2778308172 @default.
• W1794538072 hasConceptScore W1794538072C2781322055 @default.
• W1794538072 hasConceptScore W1794538072C31573885 @default.
• W1794538072 hasConceptScore W1794538072C42362537 @default.
• W1794538072 hasConceptScore W1794538072C502942594 @default.
• W1794538072 hasConceptScore W1794538072C55493867 @default.
• W1794538072 hasConceptScore W1794538072C62478195 @default.
• W1794538072 hasConceptScore W1794538072C75217442 @default.
• W1794538072 hasConceptScore W1794538072C86554907 @default.
• W1794538072 hasConceptScore W1794538072C86803240 @default.
• W1794538072 hasConceptScore W1794538072C95444343 @default.
• W1794538072 hasIssue "22" @default.
• W1794538072 hasLocation W17945380721 @default.
• W1794538072 hasOpenAccess W1794538072 @default.
• W1794538072 hasPrimaryLocation W17945380721 @default.
• W1794538072 hasRelatedWork W2008679478 @default.
• W1794538072 hasRelatedWork W2013592072 @default.
• W1794538072 hasRelatedWork W2049090298 @default.
• W1794538072 hasRelatedWork W2049828715 @default.
• W1794538072 hasRelatedWork W2068474242 @default.
• W1794538072 hasRelatedWork W2075439952 @default.
• W1794538072 hasRelatedWork W2085679570 @default.

• next