FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1794575150> ?p ?o ?g. }

• W1794575150 endingPage "622" @default.
• W1794575150 startingPage "622" @default.
• W1794575150 abstract "Hyaluronan (HA) is a high molecular weight glycosaminoglycan of the extracellular matrix (ECM), which is particularly abundant in soft connective tissues. Solutions of HA can be highly viscous with non-Newtonian flow properties. These properties affect the movement of HA-containing fluid layers within and underlying the deep fascia. Changes in the concentration, molecular weight, or even covalent modification of HA in inflammatory conditions, as well as changes in binding interactions with other macromolecules, can have dramatic effects on the sliding movement of fascia. The high molecular weight and the semi-flexible chain of HA are key factors leading to the high viscosity of dilute solutions, and real HA solutions show additional nonideality and greatly increased viscosity due to mutual macromolecular crowding. The shear rate dependence of the viscosity, and the viscoelasticity of HA solutions, depend on the relaxation time of the molecule, which in turn depends on the HA concentration and molecular weight. Temperature can also have an effect on these properties. High viscosity can additionally affect the lubricating function of HA solutions. Immobility can increase the concentration of HA, increase the viscosity, and reduce lubrication and gliding of the layers of connective tissue and muscle. Over time, these changes can alter both muscle structure and function. Inflammation can further increase the viscosity of HA-containing fluids if the HA is modified via covalent attachment of heavy chains derived from Inter-α-Inhibitor. Hyaluronidase hydrolyzes HA, thus reducing its molecular weight, lowering the viscosity of the extracellular matrix fluid and making outflow easier. It can also disrupt any aggregates or gel-like structures that result from HA being modified. Hyaluronidase is used medically primarily as a dispersion agent, but may also be useful in conditions where altered viscosity of the fascia is desired, such as in the treatment of muscle stiffness." @default.
• W1794575150 created "2016-06-24" @default.
• W1794575150 creator A5003081844 @default.
• W1794575150 creator A5010138020 @default.
• W1794575150 creator A5019962521 @default.
• W1794575150 creator A5028697334 @default.
• W1794575150 date "2015-08-25" @default.
• W1794575150 modified "2023-10-17" @default.
• W1794575150 title "Viscoelastic Properties of Hyaluronan in Physiological Conditions" @default.
• W1794575150 cites W1467899359 @default.
• W1794575150 cites W1502902953 @default.
• W1794575150 cites W1543809841 @default.
• W1794575150 cites W163068442 @default.
• W1794575150 cites W1741822416 @default.
• W1794575150 cites W1967179462 @default.
• W1794575150 cites W1969548917 @default.
• W1794575150 cites W1974949986 @default.
• W1794575150 cites W1978807770 @default.
• W1794575150 cites W1981852314 @default.
• W1794575150 cites W1987128684 @default.
• W1794575150 cites W1991762973 @default.
• W1794575150 cites W1995061614 @default.
• W1794575150 cites W1997793046 @default.
• W1794575150 cites W1999562066 @default.
• W1794575150 cites W2000119421 @default.
• W1794575150 cites W2003380614 @default.
• W1794575150 cites W2003539081 @default.
• W1794575150 cites W2004274411 @default.
• W1794575150 cites W2005289866 @default.
• W1794575150 cites W2007515745 @default.
• W1794575150 cites W2008465593 @default.
• W1794575150 cites W2009275174 @default.
• W1794575150 cites W2018754317 @default.
• W1794575150 cites W2026139437 @default.
• W1794575150 cites W2030670140 @default.
• W1794575150 cites W2034395533 @default.
• W1794575150 cites W2039475600 @default.
• W1794575150 cites W2044475547 @default.
• W1794575150 cites W2053405152 @default.
• W1794575150 cites W2057369215 @default.
• W1794575150 cites W2058163164 @default.
• W1794575150 cites W2062317324 @default.
• W1794575150 cites W2070365054 @default.
• W1794575150 cites W2071708686 @default.
• W1794575150 cites W2072773716 @default.
• W1794575150 cites W2073504492 @default.
• W1794575150 cites W2074004998 @default.
• W1794575150 cites W2077872054 @default.
• W1794575150 cites W2082000832 @default.
• W1794575150 cites W2082703895 @default.
• W1794575150 cites W2092704138 @default.
• W1794575150 cites W2093722274 @default.
• W1794575150 cites W2094918470 @default.
• W1794575150 cites W2097847761 @default.
• W1794575150 cites W2103836570 @default.
• W1794575150 cites W2107778417 @default.
• W1794575150 cites W2119898835 @default.
• W1794575150 cites W2123158441 @default.
• W1794575150 cites W2132262423 @default.
• W1794575150 cites W2139966914 @default.
• W1794575150 cites W2142011208 @default.
• W1794575150 cites W2146505397 @default.
• W1794575150 cites W2152884265 @default.
• W1794575150 cites W2163103057 @default.
• W1794575150 cites W2163465628 @default.
• W1794575150 cites W2234502071 @default.
• W1794575150 cites W2335118956 @default.
• W1794575150 cites W2341904755 @default.
• W1794575150 cites W2405284913 @default.
• W1794575150 cites W2416136159 @default.
• W1794575150 cites W2434800708 @default.
• W1794575150 cites W2467949190 @default.
• W1794575150 cites W252288518 @default.
• W1794575150 cites W2624315097 @default.
• W1794575150 cites W2896227396 @default.
• W1794575150 cites W4230851866 @default.
• W1794575150 cites W4243231451 @default.
• W1794575150 cites W4301263623 @default.
• W1794575150 cites W80544987 @default.
• W1794575150 doi "https://doi.org/10.12688/f1000research.6885.1" @default.
• W1794575150 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4648226" @default.
• W1794575150 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26594344" @default.
• W1794575150 hasPublicationYear "2015" @default.
• W1794575150 type Work @default.
• W1794575150 sameAs 1794575150 @default.
• W1794575150 citedByCount "184" @default.
• W1794575150 countsByYear W17945751502016 @default.
• W1794575150 countsByYear W17945751502017 @default.
• W1794575150 countsByYear W17945751502018 @default.
• W1794575150 countsByYear W17945751502019 @default.
• W1794575150 countsByYear W17945751502020 @default.
• W1794575150 countsByYear W17945751502021 @default.
• W1794575150 countsByYear W17945751502022 @default.
• W1794575150 countsByYear W17945751502023 @default.
• W1794575150 crossrefType "journal-article" @default.
• W1794575150 hasAuthorship W1794575150A5003081844 @default.
• W1794575150 hasAuthorship W1794575150A5010138020 @default.
• W1794575150 hasAuthorship W1794575150A5019962521 @default.

• next