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• W1794698379 abstract "Retroposition is a widespread phenomenon resulting in the generation of new genes that are initially related to a parent gene via very high coding sequence similarity. We examine the evolutionary fate of four retrogenes generated by such an event; mouse Inpp5f_v2, Mcts2, Nap1l5, and U2af1-rs1. These genes are all subject to the epigenetic phenomenon of parental imprinting. We first provide new data on the age of these retrogene insertions. Using codon-based models of sequence evolution, we show these retrogenes have diverse evolutionary trajectories, including divergence from the parent coding sequence under positive selection pressure, purifying selection pressure maintaining parent-retrogene similarity, and neutral evolution. Examination of the expression pattern of retrogenes shows an atypical, broad pattern across multiple tissues. Protein 3D structure modeling reveals that a positively selected residue in U2af1-rs1, not shared by its parent, may influence protein conformation. Our case-by-case analysis of the evolution of four imprinted retrogenes reveals that this interesting class of imprinted genes, while similar in regulation and sequence characteristics, follow very varied evolutionary paths." @default.
• W1794698379 created "2016-06-24" @default.
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• W1794698379 date "2011-01-10" @default.
• W1794698379 modified "2023-09-23" @default.
• W1794698379 title "A CASE‐BY‐CASE EVOLUTIONARY ANALYSIS OF FOUR IMPRINTED RETROGENES" @default.
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• W1794698379 doi "https://doi.org/10.1111/j.1558-5646.2010.01213.x" @default.
• W1794698379 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3107425" @default.
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