FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1794835743> ?p ?o ?g. }

• W1794835743 endingPage "123" @default.
• W1794835743 startingPage "81" @default.
• W1794835743 abstract "Caenorhabditis elegans zygotes undergo a series of four differentiative divisions to generate 5 somatic founder cells and a germ-line progenitor cell by the 16- to 24-cell stage of embryogenesis. The pattern of divisions, cell positions, and development of the embryonic cells are invariant from embryo to embryo. Through a combination of embryo manipulation, treatment of embryos with pharmacologic agents, and genetic analysis of maternal-effect embryonic-lethal mutants, researchers in several laboratories have investigated when and how cell differences are generated and cell fates are specified during embryogenesis: 1. Most blastomeres develop in a cell-autonomous manner. They do not need to undergo cell division and they do not require their normal neighbors to express differentiation products characteristic of their lineage. In embryos in which specific cells have been ablated, the fates of neighboring cells do not change to compensate for the missing cells. These observations suggest that most embryonic cells are determined by lineally transmitted internally segregated information. 2. There is at least one clear-cut example of inductive interactions during early development. The anterior daughter of AB gives rise to hypodermis, neurons, pharyngeal muscles, and body wall muscles. Interactions between ABa cells and P1-derived blastomeres are required between the 4- and 28-cell stage for ABa to generate pharyngeal and body wall muscles. ABa appears to be directed to generate hypodermis by internally segregated cues and directed to generate muscle by external cues. 3. Certain of the early internal segregation events require the participation of microfilaments. Disruption of the microfilament array leads to the missegregation of germ granules and of the potential of cells to undergo unequal germ-line-like divisions. Microfilaments may be involved in many other segregation events as well. 4. Several maternal-effect lethal mutants also perturb zygotic segregation events. These par mutants, which divide symmetrically and fail to segregate germ granules, may identify genes whose products interact with microfilaments or otherwise participate in cytoplasmic localization during the early divisions." @default.
• W1794835743 created "2016-06-24" @default.
• W1794835743 creator A5018304015 @default.
• W1794835743 date "1989-01-01" @default.
• W1794835743 modified "2023-09-26" @default.
• W1794835743 title "Generation of Cell Diversity during Early Embryogenesis in the Nematode Caenorhabditis elegans" @default.
• W1794835743 cites W106780798 @default.
• W1794835743 cites W1506541560 @default.
• W1794835743 cites W1944127002 @default.
• W1794835743 cites W1948927501 @default.
• W1794835743 cites W1963816832 @default.
• W1794835743 cites W1963861612 @default.
• W1794835743 cites W1965280618 @default.
• W1794835743 cites W1966648387 @default.
• W1794835743 cites W1968943425 @default.
• W1794835743 cites W1969695222 @default.
• W1794835743 cites W1970491975 @default.
• W1794835743 cites W1972745320 @default.
• W1794835743 cites W1974501915 @default.
• W1794835743 cites W1978555647 @default.
• W1794835743 cites W1979050181 @default.
• W1794835743 cites W1980979311 @default.
• W1794835743 cites W1982824050 @default.
• W1794835743 cites W1984944970 @default.
• W1794835743 cites W1986006829 @default.
• W1794835743 cites W1987248266 @default.
• W1794835743 cites W1989952069 @default.
• W1794835743 cites W1997105806 @default.
• W1794835743 cites W2000929749 @default.
• W1794835743 cites W2004158281 @default.
• W1794835743 cites W2004914865 @default.
• W1794835743 cites W2006130293 @default.
• W1794835743 cites W2007829919 @default.
• W1794835743 cites W2008139615 @default.
• W1794835743 cites W2014260482 @default.
• W1794835743 cites W2014847218 @default.
• W1794835743 cites W2015468345 @default.
• W1794835743 cites W2018264362 @default.
• W1794835743 cites W2021002226 @default.
• W1794835743 cites W2021060386 @default.
• W1794835743 cites W2021095556 @default.
• W1794835743 cites W2025322129 @default.
• W1794835743 cites W2031305956 @default.
• W1794835743 cites W2033956819 @default.
• W1794835743 cites W2035707307 @default.
• W1794835743 cites W2036742579 @default.
• W1794835743 cites W2037102374 @default.
• W1794835743 cites W2037634298 @default.
• W1794835743 cites W2038029561 @default.
• W1794835743 cites W2038948621 @default.
• W1794835743 cites W2039785559 @default.
• W1794835743 cites W2044810100 @default.
• W1794835743 cites W2052477009 @default.
• W1794835743 cites W2053753856 @default.
• W1794835743 cites W2056304596 @default.
• W1794835743 cites W2057073888 @default.
• W1794835743 cites W2062118692 @default.
• W1794835743 cites W2063027003 @default.
• W1794835743 cites W2072627483 @default.
• W1794835743 cites W2077440549 @default.
• W1794835743 cites W2080942738 @default.
• W1794835743 cites W2083572891 @default.
• W1794835743 cites W2091153798 @default.
• W1794835743 cites W2092955450 @default.
• W1794835743 cites W2093743411 @default.
• W1794835743 cites W2102234071 @default.
• W1794835743 cites W2104504789 @default.
• W1794835743 cites W2116241226 @default.
• W1794835743 cites W2129900247 @default.
• W1794835743 cites W2130995821 @default.
• W1794835743 cites W2160938187 @default.
• W1794835743 cites W2161282555 @default.
• W1794835743 cites W2165744297 @default.
• W1794835743 cites W2329066100 @default.
• W1794835743 cites W959573113 @default.
• W1794835743 cites W960900776 @default.
• W1794835743 doi "https://doi.org/10.1016/s0074-7696(08)60859-1" @default.
• W1794835743 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2661459" @default.
• W1794835743 hasPublicationYear "1989" @default.
• W1794835743 type Work @default.
• W1794835743 sameAs 1794835743 @default.
• W1794835743 citedByCount "25" @default.
• W1794835743 crossrefType "book-chapter" @default.
• W1794835743 hasAuthorship W1794835743A5018304015 @default.
• W1794835743 hasConcept C104317684 @default.
• W1794835743 hasConcept C129536746 @default.
• W1794835743 hasConcept C134305767 @default.
• W1794835743 hasConcept C145103041 @default.
• W1794835743 hasConcept C1491633281 @default.
• W1794835743 hasConcept C163952510 @default.
• W1794835743 hasConcept C194058213 @default.
• W1794835743 hasConcept C196843134 @default.
• W1794835743 hasConcept C2778944004 @default.
• W1794835743 hasConcept C2780915607 @default.
• W1794835743 hasConcept C28748434 @default.
• W1794835743 hasConcept C2909761498 @default.
• W1794835743 hasConcept C45472230 @default.
• W1794835743 hasConcept C54355233 @default.

• next