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• W1794982713 abstract "The function of mucosal dendritic cell (DC) subsets in immunity and inflammation is not well understood. In this study, we define four DC subsets present within the lamina propria and mesenteric lymph node compartments based on expression of CD103 and CD11b. Using IL-12p40 YFP (Yet40) reporter mice, we show that CD103(+)CD11b(-) mucosal DCs are primary in vivo sources of IL-12p40; we also identified CD103(-)CD11b(-) mucosal DCs as a novel population producing this cytokine. Infection was preferentially found in CD11b(+) DCs that were negative for CD103. Lamina propria DCs containing parasites were negative for IL-12p40. Instead, production of the cytokine was strictly a property of noninfected cells. We also show that vitamin A metabolism, as measured by ALDH activity, was preferentially found in CD103(+)CD11b(+) DC and was strongly downregulated in all mucosal DC subsets during infection. Finally, overall apoptosis of lamina propria DC subsets was increased during infection. Combined, these results highlight the ability of intestinal Toxoplasma infection to alter mucosal DC activity at both the whole population level and at the level of individual subsets." @default.
• W1794982713 created "2016-06-24" @default.
• W1794982713 creator A5011387477 @default.
• W1794982713 creator A5039434595 @default.
• W1794982713 date "2015-08-17" @default.
• W1794982713 modified "2023-10-13" @default.
• W1794982713 title "Impact of<i>Toxoplasma gondii</i>on Dendritic Cell Subset Function in the Intestinal Mucosa" @default.
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• W1794982713 doi "https://doi.org/10.4049/jimmunol.1501137" @default.
• W1794982713 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4561193" @default.
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