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- W179498732 abstract "This chapter discusses the pulse-to-pulse modulation of noradrenaline (NA) release through a prejunctional α-receptor auto-inhibitory mechanism. The S-I efflux evoked by stimulation at 5 Hz for 30 s was increased by PBZ in a concentration-dependent manner. In striking contrast to the findings with atria, the S-I efflux/pulse did not fall with increasing numbers of pulses below that with a single pulse. It was increased in the range of 2–16 pulses. The finding suggests that transmitter NA was not accumulating in sufficient concentration to exert an inhibitory effect on subsequent release with the particular regime of stimulation. The S-I efflux/pulse rose to a peak of 77 ± 10 d/min at 5 Hz, and decreased with increasing frequencies to 30.5 ± 4.6 d/min at 20 Hz, and 6.9 ± 0.98 d/min at 50 Hz. A possible explanation is that transmitter NA accumulates in sufficient concentration to exert its inhibitory presynaptic effect on further release only when the stimulation frequency is above 5 Hz, and however, other mechanisms may also account for decreased transmitter release with high frequencies of stimulation." @default.
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- W179498732 date "1973-01-01" @default.
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- W179498732 title "PULSE-TO-PULSE MODULATION OF NORADRENALINE RELEASE THROUGH A PREJUNCTIONAL α-RECEPTOR AUTO-INHIBITORY MECHANISM" @default.
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- W179498732 doi "https://doi.org/10.1016/b978-0-08-017922-3.50105-2" @default.
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