Matches in SemOpenAlex for { <https://semopenalex.org/work/W1796105704> ?p ?o ?g. }
- W1796105704 endingPage "3906" @default.
- W1796105704 startingPage "3900" @default.
- W1796105704 abstract "Abstract Coccidioides posadasii causes coccidioidomycosis, or Valley fever, in the endemic regions of the Southwestern United States. The susceptibility to C. posadasii infection has been attributed to a decreased Th1 cellular response. APCs, especially dendritic cells (DCs), play an important role in the activation of Th1 response. In this study, we investigated the efficacy of a DC-based vaccine against C. posadasii in a mouse model of coccidioidomycosis. We intranasally immunized C57BL6 mice with syngeneic, bone marrow-derived DCs (JAWS II cells) transfected with a cDNA encoding the protective Coccidioides-Ag2/proline-rich Ag. The immunized mice were lethally challenged with C. posadasii through either an i.p. or intranasal route. Upon necropsy after 10 days of infection, fungal burden in lung and spleen of immunized mice was significantly reduced as compared with the control animals. The lung tissue homogenates of immunized animals showed higher levels of IFN-γ. Histologically, lung tissues of immunized mice were in better condition than the control mice. To further investigate, we studied the biodistribution and trafficking of injected DCs by nuclear imaging techniques. For this purpose, the transfected DCs were radiolabeled with 111In-oxime. Scintigraphic images showed that most of the label remained in the gastrointestinal tract. A significant amount was also observed in lung, but there were negligible circulating 111In label in blood. The results suggest that the DCs have a potent immunostimulatory activity, and immunization with DCs transfected with Ag2/proline-rich Ag-cDNA induces protective immunity against C. posadasii in C57BL6 mice." @default.
- W1796105704 created "2016-06-24" @default.
- W1796105704 creator A5006430684 @default.
- W1796105704 creator A5008042355 @default.
- W1796105704 creator A5084476092 @default.
- W1796105704 creator A5091711589 @default.
- W1796105704 date "2005-09-15" @default.
- W1796105704 modified "2023-09-27" @default.
- W1796105704 title "Efficacy of Antigen 2/Proline-Rich Antigen cDNA-Transfected Dendritic Cells in Immunization of Mice against <i>Coccidioides posadasii</i>" @default.
- W1796105704 cites W123987662 @default.
- W1796105704 cites W1534641573 @default.
- W1796105704 cites W1860329965 @default.
- W1796105704 cites W1958905182 @default.
- W1796105704 cites W1963964961 @default.
- W1796105704 cites W1964878264 @default.
- W1796105704 cites W1967879315 @default.
- W1796105704 cites W1971165889 @default.
- W1796105704 cites W1972687276 @default.
- W1796105704 cites W1975344783 @default.
- W1796105704 cites W1988338839 @default.
- W1796105704 cites W1990050426 @default.
- W1796105704 cites W2010788447 @default.
- W1796105704 cites W2013299453 @default.
- W1796105704 cites W2017231245 @default.
- W1796105704 cites W2020360709 @default.
- W1796105704 cites W2035624263 @default.
- W1796105704 cites W2041179764 @default.
- W1796105704 cites W2047935185 @default.
- W1796105704 cites W2088948188 @default.
- W1796105704 cites W2096335976 @default.
- W1796105704 cites W2098637409 @default.
- W1796105704 cites W2114101084 @default.
- W1796105704 cites W2114192025 @default.
- W1796105704 cites W2119456625 @default.
- W1796105704 cites W2121691225 @default.
- W1796105704 cites W2123463800 @default.
- W1796105704 cites W2126065441 @default.
- W1796105704 cites W2132572684 @default.
- W1796105704 cites W2132980040 @default.
- W1796105704 cites W2139270181 @default.
- W1796105704 cites W2139471924 @default.
- W1796105704 cites W2145959854 @default.
- W1796105704 cites W2152787894 @default.
- W1796105704 cites W2153910927 @default.
- W1796105704 cites W2169341339 @default.
- W1796105704 cites W2195029035 @default.
- W1796105704 cites W4321429409 @default.
- W1796105704 cites W94773966 @default.
- W1796105704 doi "https://doi.org/10.4049/jimmunol.175.6.3900" @default.
- W1796105704 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16148136" @default.
- W1796105704 hasPublicationYear "2005" @default.
- W1796105704 type Work @default.
- W1796105704 sameAs 1796105704 @default.
- W1796105704 citedByCount "34" @default.
- W1796105704 countsByYear W17961057042012 @default.
- W1796105704 countsByYear W17961057042013 @default.
- W1796105704 countsByYear W17961057042014 @default.
- W1796105704 countsByYear W17961057042015 @default.
- W1796105704 countsByYear W17961057042016 @default.
- W1796105704 countsByYear W17961057042017 @default.
- W1796105704 countsByYear W17961057042018 @default.
- W1796105704 countsByYear W17961057042019 @default.
- W1796105704 countsByYear W17961057042020 @default.
- W1796105704 countsByYear W17961057042021 @default.
- W1796105704 crossrefType "journal-article" @default.
- W1796105704 hasAuthorship W1796105704A5006430684 @default.
- W1796105704 hasAuthorship W1796105704A5008042355 @default.
- W1796105704 hasAuthorship W1796105704A5084476092 @default.
- W1796105704 hasAuthorship W1796105704A5091711589 @default.
- W1796105704 hasBestOaLocation W17961057041 @default.
- W1796105704 hasConcept C147483822 @default.
- W1796105704 hasConcept C153911025 @default.
- W1796105704 hasConcept C159047783 @default.
- W1796105704 hasConcept C203014093 @default.
- W1796105704 hasConcept C2780801004 @default.
- W1796105704 hasConcept C2780931953 @default.
- W1796105704 hasConcept C54009773 @default.
- W1796105704 hasConcept C54355233 @default.
- W1796105704 hasConcept C81885089 @default.
- W1796105704 hasConcept C86803240 @default.
- W1796105704 hasConcept C89423630 @default.
- W1796105704 hasConceptScore W1796105704C147483822 @default.
- W1796105704 hasConceptScore W1796105704C153911025 @default.
- W1796105704 hasConceptScore W1796105704C159047783 @default.
- W1796105704 hasConceptScore W1796105704C203014093 @default.
- W1796105704 hasConceptScore W1796105704C2780801004 @default.
- W1796105704 hasConceptScore W1796105704C2780931953 @default.
- W1796105704 hasConceptScore W1796105704C54009773 @default.
- W1796105704 hasConceptScore W1796105704C54355233 @default.
- W1796105704 hasConceptScore W1796105704C81885089 @default.
- W1796105704 hasConceptScore W1796105704C86803240 @default.
- W1796105704 hasConceptScore W1796105704C89423630 @default.
- W1796105704 hasIssue "6" @default.
- W1796105704 hasLocation W17961057041 @default.
- W1796105704 hasLocation W17961057042 @default.
- W1796105704 hasOpenAccess W1796105704 @default.
- W1796105704 hasPrimaryLocation W17961057041 @default.
- W1796105704 hasRelatedWork W1994735423 @default.