Matches in SemOpenAlex for { <https://semopenalex.org/work/W179616580> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W179616580 abstract "A major role of the Saccharomyces cerevisiae MGA2 gene product is regulation of unsaturated fatty acid production, by controlling transcription and mRNA stability of OLE1, the gene encoding the ?-9 fatty acid desaturase. Lipid composition studies indicated that the mga2? strain contains elevated relative amounts of squalene when compared to wild-type cells. The deletion of the MGA2 homologue, SPT23, does not similarly impact squalene amounts. To explore the role of MGA2 in the regulation of sterol synthesis, ERG1 transcription was studied using an ERG1 promoter-lacZ reporter gene construct. We report here that in addition to Mga2p's role in regulation of unsaturated fatty acids, MGA2 is required for full basal expression of ERG1. Mga2p was found to differentially regulate activation of ERG1 and OLE1, as unsaturated fatty acids did not affect ERG1 expression levels as has previously been shown to control Mga2p's activation of OLE1. The spt23? strain shows similar ERG1 expression to wild-type cells, while the mga2?/spt23? strain shows reduced ERG1 expression, comparable to the mga2? mutant alone, suggesting that the role of regulation of ERG1 transcription is unique to Mga2p. Finally, particular exogenous unsaturated fatty acid supplementation was shown to influence cellular relative squalene amounts, which was less dependent on genotype. CR was supported by a Deans Research Award" @default.
- W179616580 created "2016-06-24" @default.
- W179616580 creator A5024641108 @default.
- W179616580 creator A5054413216 @default.
- W179616580 creator A5068176375 @default.
- W179616580 date "2009-04-01" @default.
- W179616580 modified "2023-09-27" @default.
- W179616580 title "A role for MGA2, but not SPT23, in activation of transcription of ERG1 in Saccharomyces cerevisiae" @default.
- W179616580 doi "https://doi.org/10.1096/fasebj.23.1_supplement.689.13" @default.
- W179616580 hasPublicationYear "2009" @default.
- W179616580 type Work @default.
- W179616580 sameAs 179616580 @default.
- W179616580 citedByCount "0" @default.
- W179616580 crossrefType "journal-article" @default.
- W179616580 hasAuthorship W179616580A5024641108 @default.
- W179616580 hasAuthorship W179616580A5054413216 @default.
- W179616580 hasAuthorship W179616580A5068176375 @default.
- W179616580 hasBestOaLocation W1796165801 @default.
- W179616580 hasConcept C104317684 @default.
- W179616580 hasConcept C138885662 @default.
- W179616580 hasConcept C143065580 @default.
- W179616580 hasConcept C150194340 @default.
- W179616580 hasConcept C153911025 @default.
- W179616580 hasConcept C179926584 @default.
- W179616580 hasConcept C185592680 @default.
- W179616580 hasConcept C19038510 @default.
- W179616580 hasConcept C27153228 @default.
- W179616580 hasConcept C2776703722 @default.
- W179616580 hasConcept C2777129432 @default.
- W179616580 hasConcept C2777576037 @default.
- W179616580 hasConcept C3020713888 @default.
- W179616580 hasConcept C41895202 @default.
- W179616580 hasConcept C543025807 @default.
- W179616580 hasConcept C553450214 @default.
- W179616580 hasConcept C55493867 @default.
- W179616580 hasConcept C85411794 @default.
- W179616580 hasConcept C86339819 @default.
- W179616580 hasConcept C86803240 @default.
- W179616580 hasConcept C95444343 @default.
- W179616580 hasConceptScore W179616580C104317684 @default.
- W179616580 hasConceptScore W179616580C138885662 @default.
- W179616580 hasConceptScore W179616580C143065580 @default.
- W179616580 hasConceptScore W179616580C150194340 @default.
- W179616580 hasConceptScore W179616580C153911025 @default.
- W179616580 hasConceptScore W179616580C179926584 @default.
- W179616580 hasConceptScore W179616580C185592680 @default.
- W179616580 hasConceptScore W179616580C19038510 @default.
- W179616580 hasConceptScore W179616580C27153228 @default.
- W179616580 hasConceptScore W179616580C2776703722 @default.
- W179616580 hasConceptScore W179616580C2777129432 @default.
- W179616580 hasConceptScore W179616580C2777576037 @default.
- W179616580 hasConceptScore W179616580C3020713888 @default.
- W179616580 hasConceptScore W179616580C41895202 @default.
- W179616580 hasConceptScore W179616580C543025807 @default.
- W179616580 hasConceptScore W179616580C553450214 @default.
- W179616580 hasConceptScore W179616580C55493867 @default.
- W179616580 hasConceptScore W179616580C85411794 @default.
- W179616580 hasConceptScore W179616580C86339819 @default.
- W179616580 hasConceptScore W179616580C86803240 @default.
- W179616580 hasConceptScore W179616580C95444343 @default.
- W179616580 hasIssue "S1" @default.
- W179616580 hasLocation W1796165801 @default.
- W179616580 hasOpenAccess W179616580 @default.
- W179616580 hasPrimaryLocation W1796165801 @default.
- W179616580 hasRelatedWork W1483218645 @default.
- W179616580 hasRelatedWork W1539018267 @default.
- W179616580 hasRelatedWork W1589208118 @default.
- W179616580 hasRelatedWork W1757198 @default.
- W179616580 hasRelatedWork W179616580 @default.
- W179616580 hasRelatedWork W2044170667 @default.
- W179616580 hasRelatedWork W2049755488 @default.
- W179616580 hasRelatedWork W2058655151 @default.
- W179616580 hasRelatedWork W2172226517 @default.
- W179616580 hasRelatedWork W2979350365 @default.
- W179616580 hasVolume "23" @default.
- W179616580 isParatext "false" @default.
- W179616580 isRetracted "false" @default.
- W179616580 magId "179616580" @default.
- W179616580 workType "article" @default.