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- W1796275876 endingPage "87" @default.
- W1796275876 startingPage "275" @default.
- W1796275876 abstract "Atherosclerosis is the leading cause of death in industrialized countries and is becoming an increasingly worldwide risk to health. Apolipoprotein E (ApoE) is a blood circulating protein with pleiotropic atheroprotective properties that has emerged as a strong candidate for treating hypercholesterolemia and cardiovascular disease. In this review, we discuss the major developments in both viral and non-viral vectors aimed at achieving efficient delivery and sustained expression of an ApoE transgene. The technological advances in engineering viruses include cross-packaging to generate different serotypes of recombinant adeno-associated virus, and the use of multiple-deleted and helper-dependent recombinant adenovirus vectors to minimize immune responses and to package genomic loci. Non-viral ApoE delivery systems, including plasmids and cell-based therapy are also described in this review. Finally, a radical alternative to gene addition that has the potential for permanent cure in many genetic diseases--'targeted gene editing'--is reviewed. This technology uses synthetic oligonucleotides to correct underlying point mutations in situ and has been evaluated for repairing dysfunctional APOE genes." @default.
- W1796275876 created "2016-06-24" @default.
- W1796275876 creator A5009563977 @default.
- W1796275876 creator A5011158653 @default.
- W1796275876 creator A5074748092 @default.
- W1796275876 date "2006-08-01" @default.
- W1796275876 modified "2023-09-27" @default.
- W1796275876 title "ApoE gene therapy to treat hyperlipidemia and atherosclerosis." @default.
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