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- W1796285230 endingPage "162" @default.
- W1796285230 startingPage "143" @default.
- W1796285230 abstract "This chapter highlights both the generalities and the unique features of signaling pathways controlling interactions between fungal pathogens and mammalian hosts. Of the common fungal pathogens of humans, Candida albicans, Cryptococcus neoformans, and Aspergillus fumigatus have been the most extensively investigated. Although many different signal transduction cascades mediate responses of pathogens to their hosts, the most extensively investigated networks involve cAMP, MAPK, two-component histidine kinase (HK), pH pathways, and Ca2+/calmodulin signaling. The pathways can mediate different environmental conditions, such as temperature, stress, and presence of serum, within the different pathogens and induce different responses, including changes in cell morphology and expression of particular virulence factors. TLR2 and TLR4 appear to be the most important for the recognition of fungal pathogens. Both TLR2 and TLR4 play a role in the recognition of A. fumigatus and C. albicans, while C. neoformans, through its polysaccharide capsule consisting of glucuronoxylomannan, appears to be recognized uniquely by TLR4. The developing tools of knockout mice, genome sequences, cultured cell lines, and DNA microarrays have a profound impact on one's ability to define the interaction between mammalian host cells and fungal pathogens. The tools to address such questions are here or soon to arrive, the questions themselves are exciting and answerable, and the potential payoffs for understanding the signaling pathways in fungal pathogens are profound." @default.
- W1796285230 created "2016-06-24" @default.
- W1796285230 creator A5059796808 @default.
- W1796285230 creator A5062855889 @default.
- W1796285230 date "2014-04-08" @default.
- W1796285230 modified "2023-10-16" @default.
- W1796285230 title "Signal Transduction in the Interactions of Fungal Pathogens and Mammalian Hosts" @default.
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