FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1796307613> ?p ?o ?g. }

• W1796307613 endingPage "3" @default.
• W1796307613 startingPage "3" @default.
• W1796307613 abstract "In rats, two peroxisomal 3-ketoacyl-CoA thiolase genes (A and B) have been cloned, whereas only one thiolase gene is found in humans. The aim of this study was thus to clone the different mouse thiolase genes in order to study both their tissue expression and their associated enzymatic activity. In this study, we cloned and characterized two mouse peroxisomal 3-ketoacyl-CoA thiolase genes (termed thiolase A and B). Both thiolase A and B genes contain 12 exons and 11 introns. Using RNA extracted from mouse liver, we cloned the two corresponding cDNAs. Thiolase A and B cDNAs possess an open reading frame of 1272 nucleotides encoding a protein of 424 amino acids. In the coding sequence, the two thiolase genes exhibited ≈97% nucleotide sequence identity and ≈96% identity at the amino acid level. The tissue-specific expression of the two peroxisomal 3-ketoacyl-CoA thiolase genes was studied in mice. Thiolase A mRNA was mainly expressed in liver and intestine, while thiolase B mRNA essentially exhibited hepatic expression and weaker levels in kidney, intestine and white adipose tissue. Thiolase A and B expressions in the other tissues such as brain or muscle were very low though these tissues were chiefly involved in peroxisomal disorders. At the enzymatic level, thiolase activity was detected in liver, kidney, intestine and white adipose tissue but no significant difference was observed between these four tissues. Moreover, thiolase A and B genes were differently induced in liver of mice treated with fenofibrate. Two mouse thiolase genes and cDNAs were cloned. Their corresponding transcripts are mostly expressed in the liver of mice and are differently induced by fenofibrate." @default.
• W1796307613 created "2016-06-24" @default.
• W1796307613 creator A5001706516 @default.
• W1796307613 creator A5018763293 @default.
• W1796307613 creator A5032011210 @default.
• W1796307613 creator A5034619629 @default.
• W1796307613 creator A5053722341 @default.
• W1796307613 creator A5063954794 @default.
• W1796307613 creator A5089511570 @default.
• W1796307613 date "2004-01-01" @default.
• W1796307613 modified "2023-10-17" @default.
• W1796307613 cites W1481490635 @default.
• W1796307613 cites W1488135609 @default.
• W1796307613 cites W1492475114 @default.
• W1796307613 cites W1527584651 @default.
• W1796307613 cites W1573886742 @default.
• W1796307613 cites W1575549322 @default.
• W1796307613 cites W1607743281 @default.
• W1796307613 cites W1972105324 @default.
• W1796307613 cites W1976105576 @default.
• W1796307613 cites W2010783566 @default.
• W1796307613 cites W2011522912 @default.
• W1796307613 cites W2033460374 @default.
• W1796307613 cites W2038200717 @default.
• W1796307613 cites W2040682568 @default.
• W1796307613 cites W2042118085 @default.
• W1796307613 cites W2060052903 @default.
• W1796307613 cites W2062466059 @default.
• W1796307613 cites W2062933320 @default.
• W1796307613 cites W2074185831 @default.
• W1796307613 cites W2075902622 @default.
• W1796307613 cites W2097012912 @default.
• W1796307613 cites W2115149771 @default.
• W1796307613 cites W2134812217 @default.
• W1796307613 cites W2152201022 @default.
• W1796307613 cites W2159257506 @default.
• W1796307613 cites W2160464289 @default.
• W1796307613 cites W2413107236 @default.
• W1796307613 cites W2576734941 @default.
• W1796307613 cites W4244208946 @default.
• W1796307613 cites W54092335 @default.
• W1796307613 doi "https://doi.org/10.1186/1471-2091-5-3" @default.
• W1796307613 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/404372" @default.
• W1796307613 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15043762" @default.
• W1796307613 hasPublicationYear "2004" @default.
• W1796307613 type Work @default.
• W1796307613 sameAs 1796307613 @default.
• W1796307613 citedByCount "25" @default.
• W1796307613 countsByYear W17963076132013 @default.
• W1796307613 countsByYear W17963076132014 @default.
• W1796307613 countsByYear W17963076132017 @default.
• W1796307613 countsByYear W17963076132019 @default.
• W1796307613 countsByYear W17963076132020 @default.
• W1796307613 countsByYear W17963076132021 @default.
• W1796307613 countsByYear W17963076132023 @default.
• W1796307613 crossrefType "journal-article" @default.
• W1796307613 hasAuthorship W1796307613A5001706516 @default.
• W1796307613 hasAuthorship W1796307613A5018763293 @default.
• W1796307613 hasAuthorship W1796307613A5032011210 @default.
• W1796307613 hasAuthorship W1796307613A5034619629 @default.
• W1796307613 hasAuthorship W1796307613A5053722341 @default.
• W1796307613 hasAuthorship W1796307613A5063954794 @default.
• W1796307613 hasAuthorship W1796307613A5089511570 @default.
• W1796307613 hasBestOaLocation W17963076131 @default.
• W1796307613 hasConcept C104317684 @default.
• W1796307613 hasConcept C127078168 @default.
• W1796307613 hasConcept C153911025 @default.
• W1796307613 hasConcept C167625842 @default.
• W1796307613 hasConcept C187882448 @default.
• W1796307613 hasConcept C2781031557 @default.
• W1796307613 hasConcept C36823959 @default.
• W1796307613 hasConcept C47289529 @default.
• W1796307613 hasConcept C55493867 @default.
• W1796307613 hasConcept C86803240 @default.
• W1796307613 hasConceptScore W1796307613C104317684 @default.
• W1796307613 hasConceptScore W1796307613C127078168 @default.
• W1796307613 hasConceptScore W1796307613C153911025 @default.
• W1796307613 hasConceptScore W1796307613C167625842 @default.
• W1796307613 hasConceptScore W1796307613C187882448 @default.
• W1796307613 hasConceptScore W1796307613C2781031557 @default.
• W1796307613 hasConceptScore W1796307613C36823959 @default.
• W1796307613 hasConceptScore W1796307613C47289529 @default.
• W1796307613 hasConceptScore W1796307613C55493867 @default.
• W1796307613 hasConceptScore W1796307613C86803240 @default.
• W1796307613 hasIssue "1" @default.
• W1796307613 hasLocation W17963076131 @default.
• W1796307613 hasLocation W17963076132 @default.
• W1796307613 hasLocation W17963076133 @default.
• W1796307613 hasLocation W17963076134 @default.
• W1796307613 hasOpenAccess W1796307613 @default.
• W1796307613 hasPrimaryLocation W17963076131 @default.
• W1796307613 hasRelatedWork W190789117 @default.
• W1796307613 hasRelatedWork W1966988636 @default.
• W1796307613 hasRelatedWork W1989397580 @default.
• W1796307613 hasRelatedWork W2009810944 @default.
• W1796307613 hasRelatedWork W2011522912 @default.
• W1796307613 hasRelatedWork W2022653783 @default.
• W1796307613 hasRelatedWork W2075717222 @default.

• next