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• W1796457391 abstract "ABSTRACT The fluorescence, ultraviolet (UV) absorption, time resolved techniques, circular dichroism (CD), and infrared spectral methods were explored as tools to investigate the interaction between histamine H 1 drug, epinastine hydrochloride (EPN), and bovine serum albumin (BSA) under simulated physiological conditions. The experimental results showed that the quenching of the BSA by EPN was static quenching mechanism and also confirmed by lifetime measurements. The value of n close to unity indicated that one molecule of EPN was bound to protein molecule. The binding constants (K) at three different temperatures were calculated (7.1 × 10 4 , 5.5 × 10 4 , and 3.9 × 10 4 M −1 ). Based on the thermodynamic parameters (Δ H 0 , ΔG 0 , and ΔS 0 ), the nature of binding forces operating between drug and protein was proposed. The site of binding of EPN in the protein was proposed to be Sudlow's site I based on displacement experiments using site markers viz, warfarin, ibuprofen, and digitoxin. Based on the Förster's theory of non‐radiation energy transfer, the binding average distance, r between the donor (BSA) and acceptor (EPN) was evaluated and found to be 4.48 nm. The UV–visible, synchronous fluorescence, CD, and three‐dimensional fluorescence spectral results revealed the changes in secondary structure of the protein upon its interaction with EPN. © 2015 Wiley Periodicals, Inc. Biopolymers 103: 646–657, 2015." @default.
• W1796457391 created "2016-06-24" @default.
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• W1796457391 date "2015-08-22" @default.
• W1796457391 modified "2023-10-16" @default.
• W1796457391 title "Study of fluorescence interaction and conformational changes of bovine serum albumin with histamine H₁-receptor-drug epinastine hydrochloride by spectroscopic and time-resolved fluorescence methods" @default.
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• W1796457391 doi "https://doi.org/10.1002/bip.22707" @default.
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