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- W179647543 abstract "Abstract Oxindole alkaloids are a monoterpene group of alkaloids that exhibits an oxindole moiety (N–C═O) in ring B of the structure with either corynantheoid or ajmalicinoid analogues exhibiting tetracyclic or pentacyclic oxindole skeletons. The occurrence of this group of alkaloids in Uncaria species may be derived from the transition of heteroyohimbines (indole alkaloids) via indolenine intermediates brought about by differences in cell pH values. This group of alkaloids which is prevalent in Uncaria species but also exists in the related Mitragyna species has been largely explored in terms of their biological and pharmacological potential, in particular, immunomodulatory and CNS-related properties. The worldwide emergence of products containing these alkaloids as active ingredients for the treatment of various diseases was not only based on the ethnomedical use of Uncaria plants but are also a consequence of scientific evidence extensively documented on the plant's extracts and isolated compounds in the last 30 years. In this review, we shall highlight the chemical, biological, and pharmacological properties of these unique alkaloids in order to reevaluate their potential for drug development and as bioactive ingredients in herbal products and preparations." @default.
- W179647543 created "2016-06-24" @default.
- W179647543 creator A5052707270 @default.
- W179647543 creator A5053063179 @default.
- W179647543 date "2015-01-01" @default.
- W179647543 modified "2023-10-09" @default.
- W179647543 title "Oxindole Alkaloids of Uncaria (Rubiaceae, Subfamily Cinchonoideae)" @default.
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- W179647543 doi "https://doi.org/10.1016/b978-0-444-63473-3.00012-5" @default.
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