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- W1796621435 abstract "COPD as a complex disease with genetic and environmental compound, is one of the leading cause of death in worldwide. miRNAs have role in gene expression as responsible gene9s down-regulated by blocking mRNA after transcription, translation inhibition and breaking of mRNA. Aim of the study is definition a biomarker that are based on the measurement miRNA level of plasma, is specific to COPD. 20 COPD and 10 healthy control cases were included in this study. The median age was 59±6,6 and 55±5,2 years for controls and COPD, respectively. miRNA-specific quantitative real-time-PCR based miRNA (miR-qRT-PCR) detection has been used. “Free PCR Array Data Analysis Software” has been used for data analysis. As a result of the study, two miRNA were significantly upregulated (miR-7 and miR-30a) and seven different miRNA were significantly downregulated in COPD patients (miR-9, miR-20a, miR-26b, miR-28-3p, miR-34c-5p, miR-100, miR-101). As a conclusion, this is the first study using QRT PCR Array method to investigate the association between serum miRNAs and COPD. Upregulation of miR-7 and miR-30a might be potential biomarkers for early diagnosis of disease." @default.
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- W1796621435 date "2012-09-01" @default.
- W1796621435 modified "2023-10-18" @default.
- W1796621435 title "Investigation of the role of miRNAs as a biomarker in chronic obstructive pulmonary disease (COPD)" @default.
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