Matches in SemOpenAlex for { <https://semopenalex.org/work/W1796626571> ?p ?o ?g. }
- W1796626571 endingPage "443" @default.
- W1796626571 startingPage "436" @default.
- W1796626571 abstract "Linker histones are three domain proteins and consist of a structured (globular) domain, flanked by two likely non-structured NH2- and COOH-termini. The binding of the linker histones to the nucleosome was characterized by different methods in solution. Apparently, the globular domain interacts with the linker DNA and the nucleosome dyad, while the binding of the large and rich in lysines COOH-terminus results in closing the linker DNA of the nucleosome and the formation of the stem structure. What is the mode of binding of the linker histones within the chromatin fiber remains still elusive. Nonetheless, it is clear that linker histones are essential for both the assembly and maintenance of the condensed chromatin fiber. Interestingly, linker histones are post-translationally modified and how this affects both their binding to chromatin and functions is now beginning to emerge. In addition, linker histones are highly mobile in vivo, but not in vitro. No explanation of this finding is reported for the moment. The higher mobility of the linker histones should, however, have strong impact on their function. Linker histones plays an important role in gene expression regulation and other chromatin related process and their function is predominantly regulated by their posttranslational modifications. However, the detailed mechanism how the linker histones do function remains still not well understood despite numerous efforts. Here we will summarize and analyze the data on the linker histone binding to the nucleosome and the chromatin fiber and will discuss its functional consequences." @default.
- W1796626571 created "2016-06-24" @default.
- W1796626571 creator A5018186705 @default.
- W1796626571 creator A5023855573 @default.
- W1796626571 creator A5048253653 @default.
- W1796626571 date "2016-03-01" @default.
- W1796626571 modified "2023-10-05" @default.
- W1796626571 title "H1–nucleosome interactions and their functional implications" @default.
- W1796626571 cites W135309739 @default.
- W1796626571 cites W1432700569 @default.
- W1796626571 cites W1509724628 @default.
- W1796626571 cites W1516572221 @default.
- W1796626571 cites W1568313174 @default.
- W1796626571 cites W1607032234 @default.
- W1796626571 cites W1624519387 @default.
- W1796626571 cites W1773400868 @default.
- W1796626571 cites W1824325020 @default.
- W1796626571 cites W1839273246 @default.
- W1796626571 cites W1933873429 @default.
- W1796626571 cites W1968302366 @default.
- W1796626571 cites W1970500614 @default.
- W1796626571 cites W1970516552 @default.
- W1796626571 cites W1970582146 @default.
- W1796626571 cites W1975563582 @default.
- W1796626571 cites W1976420166 @default.
- W1796626571 cites W1978107331 @default.
- W1796626571 cites W1978607217 @default.
- W1796626571 cites W1979245454 @default.
- W1796626571 cites W1983801284 @default.
- W1796626571 cites W1985146942 @default.
- W1796626571 cites W1986393439 @default.
- W1796626571 cites W1986598861 @default.
- W1796626571 cites W1987907616 @default.
- W1796626571 cites W1988880727 @default.
- W1796626571 cites W1989429888 @default.
- W1796626571 cites W1993633154 @default.
- W1796626571 cites W1993646828 @default.
- W1796626571 cites W1993822465 @default.
- W1796626571 cites W1996735209 @default.
- W1796626571 cites W2000392583 @default.
- W1796626571 cites W2001200836 @default.
- W1796626571 cites W2001591980 @default.
- W1796626571 cites W2003435166 @default.
- W1796626571 cites W2005374586 @default.
- W1796626571 cites W2010048885 @default.
- W1796626571 cites W2011043347 @default.
- W1796626571 cites W2012119941 @default.
- W1796626571 cites W2014279477 @default.
- W1796626571 cites W2015987289 @default.
- W1796626571 cites W2017314177 @default.
- W1796626571 cites W2019553342 @default.
- W1796626571 cites W2022050896 @default.
- W1796626571 cites W2022328060 @default.
- W1796626571 cites W2024438743 @default.
- W1796626571 cites W2026344452 @default.
- W1796626571 cites W2026371011 @default.
- W1796626571 cites W2033097911 @default.
- W1796626571 cites W2033810913 @default.
- W1796626571 cites W2035642248 @default.
- W1796626571 cites W2037728472 @default.
- W1796626571 cites W2037780763 @default.
- W1796626571 cites W2038828962 @default.
- W1796626571 cites W2039405194 @default.
- W1796626571 cites W2039534245 @default.
- W1796626571 cites W2039751052 @default.
- W1796626571 cites W2041787701 @default.
- W1796626571 cites W2042507670 @default.
- W1796626571 cites W2046615335 @default.
- W1796626571 cites W2046772863 @default.
- W1796626571 cites W2050489395 @default.
- W1796626571 cites W2052706262 @default.
- W1796626571 cites W2054935267 @default.
- W1796626571 cites W2056902844 @default.
- W1796626571 cites W2060439764 @default.
- W1796626571 cites W2060872104 @default.
- W1796626571 cites W2064944332 @default.
- W1796626571 cites W2070603351 @default.
- W1796626571 cites W2071793084 @default.
- W1796626571 cites W2072622853 @default.
- W1796626571 cites W2073806111 @default.
- W1796626571 cites W2079105757 @default.
- W1796626571 cites W2081857390 @default.
- W1796626571 cites W2082230313 @default.
- W1796626571 cites W2083959000 @default.
- W1796626571 cites W2084634779 @default.
- W1796626571 cites W2087250202 @default.
- W1796626571 cites W2088603763 @default.
- W1796626571 cites W2097041586 @default.
- W1796626571 cites W2099114692 @default.
- W1796626571 cites W2101978443 @default.
- W1796626571 cites W2101994612 @default.
- W1796626571 cites W2105003436 @default.
- W1796626571 cites W2108000223 @default.
- W1796626571 cites W2111592257 @default.
- W1796626571 cites W2113686599 @default.
- W1796626571 cites W2117538042 @default.
- W1796626571 cites W2125302836 @default.
- W1796626571 cites W2129782312 @default.