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- W1796656135 abstract "HLA class II loci are useful markers in human population genetics, because they are extremely variable and because new molecular techniques allow large-scale analysis of DNA allele frequencies. Direct DNA typing by hybridization with sequence-specific oligonucleotide probes (HLA oligotyping) after enzymatic in vitro PCR amplification detects HLA allelic polymorphisms for all class II loci. A detailed HLA-DR oligotyping analysis of 191 individuals from a geographically, culturally, and genetically well-defined western African population, the Mandenkalu, reveals a high degree of polymorphism, with at least 24 alleles and a heterozygosity level of .884 for the DRB1 locus. The allele DRB1*1304, defined by DNA sequencing of the DRB1 first-domain exon, is the most frequent allele (27.1%). It accounts for an unusually high DR13 frequency, which is nevertheless within the neutral frequency range. The next most frequent specificities are DR11, DR3, and DR8. Among DRB3-encoded alleles, DR52b (DRB3*02) represents as much as 80.7% of all DR52 haplotypes. A survey of HLA-DR specificities in populations from different continents shows a significant positive correlation between genetic and geographic differentiation patterns. A homozygosity test for selective neutrality of DR specificities is not significant for the Mandenka population but is rejected for 20 of 24 populations. Observed high heterozygosity levels in tested populations are compatible with an overdominant model with a small selective advantage for heterozygotes." @default.
- W1796656135 created "2016-06-24" @default.
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- W1796656135 date "1992-09-01" @default.
- W1796656135 modified "2023-09-23" @default.
- W1796656135 title "HLA-DR polymorphism in a Senegalese Mandenka population: DNA oligotyping and population genetics of DRB1 specificities." @default.
- W1796656135 cites W1408645568 @default.
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- W1796656135 cites W1517480469 @default.
- W1796656135 cites W1522399766 @default.
- W1796656135 cites W1560386025 @default.
- W1796656135 cites W1823694705 @default.
- W1796656135 cites W1903982198 @default.
- W1796656135 cites W1949345268 @default.
- W1796656135 cites W1964892809 @default.
- W1796656135 cites W1966043871 @default.
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- W1796656135 cites W1971987687 @default.
- W1796656135 cites W1976612191 @default.
- W1796656135 cites W1980288711 @default.
- W1796656135 cites W1982270720 @default.
- W1796656135 cites W1982430057 @default.
- W1796656135 cites W1985227491 @default.
- W1796656135 cites W1985426707 @default.
- W1796656135 cites W1988122531 @default.
- W1796656135 cites W1988129408 @default.
- W1796656135 cites W1999212907 @default.
- W1796656135 cites W2001294676 @default.
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- W1796656135 cites W2031400421 @default.
- W1796656135 cites W2040911308 @default.
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