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- W1796692248 endingPage "140" @default.
- W1796692248 startingPage "122" @default.
- W1796692248 abstract "Any substance secreted in bile which is reabsorbed from the intestine and returns to the liver to appear once again in bile may be said to undergo an enterohepatic circulation (EHe). Accepting this defini tion, the list of endogenous and exogenous substances with an EHe is formidable. The lipids in bile, cholesterol, phospho lipids, and bile salts, provide examples of endogenous substances which all undergo enterohepatic circulations but with widely differing efficiencies (assuming that 100% absorption and reexcretion is the most ef ficient EHe). Of these biliary lipids, the EHe of bile salts is the most important but since individual molecules of both cho lesterol and lecithin, the principal phos pholipid in bile, may also circulate from bile to intestine and back to the liver and bile, they may be considered as having an EHe. Based on studies with labeled cholesterol, an EHe for cholesterol was postulated in 1952 1 and later by other authors. 2-~ Endogenous biliary cholesterol is probably mainly absorbed in the je junum 5 and of this reabsorbed fraction, a small percentage may reappear in bile hav ing followed the circuitous route of lym phatic transport, systemic circulation, hepatic artery, liver, ~md bile. However, there are many intermediate pools in which the individual cholesterol molecule may become sidetracked on the way and cholesterol, therefore, does not undergo" @default.
- W1796692248 created "2016-06-24" @default.
- W1796692248 creator A5035350690 @default.
- W1796692248 date "1972-01-01" @default.
- W1796692248 modified "2023-10-07" @default.
- W1796692248 title "The Enterohepatic Circulation" @default.
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