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• W179674344 abstract "Background: Viral infections are frequent in hemodialysis patients, notably those due to hepatitis C virus (HCV), hepatitis B virus (HBV), hepatitis G virus (HGV) cytomegalovirus (CMV) and human immunodeficiency virus (HIV). Objective: The aim of this work is to study the prevalence of viral infections among Egyptian children with end stage renal disease whether on conservative management or on hemodialysis and to identify the possible associations between viral infections and some clinical parameters. Subjects: This cross-section study included 50 patients with end stage renal disease. They were divided into two groups; the first group consisted of 20 patients on conservative management. The second group consisted of 30 patients on regular hemodialysis. Inclusion criteria: Children below 18 years, both gender, end stage renal disease patients whether on conservative management or on hemodialysis. Exclusion criteria: Patients on immunosuppressant treatment for any particular disease. M ethods: All patients were subjected to full history, thorough clinical examination and laboratory investigations in the form of complete blood count, renal function tests, and serum electrolytes. Abdominal ultrasound and echocardiography were also done. In addition virological screen was assessed (conventional PCR for HCV, HGV and CMV and ELISA for HBV, HCV and HIV). Results: The comparative study between patients on conservative management (group I) and patients on hemodialysis (group II) showed no statistical significant difference between the two groups as regard to gender and age. 60% of the examined patients in each group were male. The mean age in group I was 11.48 ± 4.06 year while in group II it was 10.27 ± 3.20 year (P=0.253). However, great statistical differences was found between both groups in the mean onset of chronic renal failure it was 5.93 ±2.67 year in group I and 3.40 ± 1.30 year in group II (P=0.002). Also significant statistical differences were found between both groups as regard to the presence of anemia, (P=0.000) and history of blood transfusions (P =0.002). 100% of hemodialysis patients had anemia and 86.7% of them received blood. Hypertension was present in 35% of group I and in 63.3% of group II pa tients (P= 0.049). Stunted growth was found in 50% of patients on conservative management and in 83.3% of patients on hemodialysis (P=0.012). Laboratory studies showed no statistical significant differences between both groups as regard to hemoglobin, hematocrit, ALT, AST, calcium, phosphorus and alkaline phosphatase enzyme. Also no statistical significant difference was found in blood urea between both groups. W hereas there was a significant statistical difference in creatinine level between the two groups. The mean creatinine level in group I patients = 3.49 ± 1.72 mg/dl while in hemodialysis patients =7.16 ± 1.41 mg/dl (P=0.000). Abdominal ultrasound showed that the common cause of chronic renal failure (CRF) in patients on conservative management was obstructive uropathies (60% of cases). W hile congenital malformations were the commonest cause of CRF in hemodialysis patients (60%). Echocardiography showed that 50% and 10% of hemodialysis patients had left ventricular hypertrophy and pericardial effusion respectively. The virological studies showed that the commonest viral infection in both groups was HCV. It was detected by PCR in 35% of group I and in 50% of group II patients as single infection or as coinfection with other viruses. Cytomegalovirus was present in 20% of group I and in 10% of group II patients. HGV was only present in hemodialysis patients (13.3% of cases). HCV antibodies were detected by ELISA test in 15% of patient on conservative management and in 43.3% of patients on hemodialysis therapy P =0.035. No antibodies for HBV and HIV were detected in our patients. Significant association was found between viral infections and patient's age (P= 0.043). Also significant association was found between viral infections and duration of hemodialysis (P=0.015). But no signifi cant associations were found between viral infections and both frequency of dialysis settings (P=0.485) and patient's gender (p=0.361). Conclusion and Recommendations: Viral infections are frequent in hemodialysis patients." @default.
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• W179674344 date "2009-01-01" @default.
• W179674344 modified "2023-09-23" @default.
• W179674344 title "Prevalence of Viral Infection among Egyptian Children with End Stage Renal Disease" @default.
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