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- W1796747034 abstract "Our recent studies have demonstrated that microRNA miR-1291 may play an important role in the regulation of tumorigenesis of pancreatic cancer cells. To understand the underlying mechanisms, we employed a LC/MS-based metabolomics approach to determine the impact of miR-1291 on pancreatic carcinoma cell metabolism. Our data showed that the miR-1291 stably transfected and control PANC-1 cells are readily segregated based upon their metabolomic profiles. A number of significantly altered cellular metabolites were identified, including 1-methylnicotinamide (MNA), taurine, L-carnitine, isobutyryl-carnitine, isovaleryl-carnitine and hydroxybutyryl-carnitine. Among them, MNA was altered to the greatest extent, and the increase in cellular MNA was associated with a sharply elevated expression of nicotinamide N-methyltransferase (NNMT). In addition, NNMT mRNA expression was inversely related to the size of PANC-1 derived xenograft tumors. Our results suggest that MNA and NNMT are possible biomarkers in miR-1291-altered pancreatic carcinoma cell metabolism. The findings may help identify key metabolic pathways in PANC-1 cells perturbed by miR-1291 and understand their involvement in pancreatic tumorigenesis." @default.
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- W1796747034 date "2014-04-01" @default.
- W1796747034 modified "2023-10-02" @default.
- W1796747034 title "Metabolomics reveals 1‐methylnicotinamide and nicotinamide N‐methyltransferase as crucial biomarkers in microRNA‐1291‐altered pancreatic carcinoma cell metabolism (1147.1)" @default.
- W1796747034 doi "https://doi.org/10.1096/fasebj.28.1_supplement.1147.1" @default.
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