FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1796764> ?p ?o ?g. }

• W1796764 endingPage "107" @default.
• W1796764 startingPage "75" @default.
• W1796764 abstract "Although the existence of a functional relationship between the pituitary gland and the adrenal cortex was revealed by the classic studies of Smith almost seventy years ago (1),the first purified adrenocorticotropin (ACTH) preparation from sheep pituitary was obtained only in 1954 (2), and its structure was determined in the following few years (3). In the 1960s, it was shown that ACTH stimulated cyclic adenosine monophosphate (cAMP) production by bovine adrenocortical slices and that cAMP itself could stimulate steroidogenesis, suggesting the role of cAMP as an obligatory mediator of the effects of ACTH (4). Moreover, several groups presented evidence that the hormones did not have to enter cells to stimulate steroidogenesis, since anti-ACTH antibody added several minutes after ACTH obliterated this effect (5) and ACTH[1–24] linked to cellulose was able to stimulate steroidogenesis of Y-1 adrenal tumor cells (6). Finally, the presence of specific binding of 125I-ACTH[1–39] to adrenal cell subcellular fraction, which contained ACTH-sensitive adenylate cyclase activity, was demonstrated in 1971 (7). Taken together, these findings led to the proposition that the initial event in the action of ACTH on adrenal cells was the binding of the hormone with specific receptors on the cell membrane leading to stimulation of adenylate cyclase and an increase in cAMP production, which in turn mediates an increase in steroidogenesis (8). This classical schema of the mechanism of ACTH action has been questioned for several reasons." @default.
• W1796764 created "2016-06-24" @default.
• W1796764 creator A5003981060 @default.
• W1796764 creator A5082177855 @default.
• W1796764 date "2000-01-01" @default.
• W1796764 modified "2023-10-16" @default.
• W1796764 title "Melanocortins and Adrenocortical Function" @default.
• W1796764 cites W125781064 @default.
• W1796764 cites W1770189426 @default.
• W1796764 cites W1831346350 @default.
• W1796764 cites W1853528204 @default.
• W1796764 cites W1964074039 @default.
• W1796764 cites W1965979252 @default.
• W1796764 cites W1968355311 @default.
• W1796764 cites W1969730155 @default.
• W1796764 cites W1969744609 @default.
• W1796764 cites W1970614438 @default.
• W1796764 cites W1972876951 @default.
• W1796764 cites W1973596394 @default.
• W1796764 cites W1973609826 @default.
• W1796764 cites W1973999556 @default.
• W1796764 cites W1974350281 @default.
• W1796764 cites W1975210948 @default.
• W1796764 cites W1975286415 @default.
• W1796764 cites W1976472536 @default.
• W1796764 cites W1977873240 @default.
• W1796764 cites W1979420492 @default.
• W1796764 cites W1980201183 @default.
• W1796764 cites W1984277590 @default.
• W1796764 cites W1986015863 @default.
• W1796764 cites W1988380853 @default.
• W1796764 cites W1988388306 @default.
• W1796764 cites W1990865193 @default.
• W1796764 cites W1993421181 @default.
• W1796764 cites W1994653551 @default.
• W1796764 cites W1994916001 @default.
• W1796764 cites W1995401293 @default.
• W1796764 cites W1995783259 @default.
• W1796764 cites W2002527589 @default.
• W1796764 cites W2005714930 @default.
• W1796764 cites W2005730770 @default.
• W1796764 cites W2006201111 @default.
• W1796764 cites W2008390141 @default.
• W1796764 cites W2010885000 @default.
• W1796764 cites W2012670862 @default.
• W1796764 cites W2014050094 @default.
• W1796764 cites W2016684961 @default.
• W1796764 cites W2018392851 @default.
• W1796764 cites W2018953521 @default.
• W1796764 cites W2019480627 @default.
• W1796764 cites W2019561037 @default.
• W1796764 cites W2024431221 @default.
• W1796764 cites W2026273928 @default.
• W1796764 cites W2026459241 @default.
• W1796764 cites W2027266914 @default.
• W1796764 cites W2031748215 @default.
• W1796764 cites W2032860381 @default.
• W1796764 cites W2033286224 @default.
• W1796764 cites W2033570148 @default.
• W1796764 cites W2036740014 @default.
• W1796764 cites W2037377299 @default.
• W1796764 cites W2037849137 @default.
• W1796764 cites W2038513777 @default.
• W1796764 cites W2039490460 @default.
• W1796764 cites W2039843633 @default.
• W1796764 cites W2040687221 @default.
• W1796764 cites W2041896576 @default.
• W1796764 cites W2042262357 @default.
• W1796764 cites W2042936777 @default.
• W1796764 cites W2043475832 @default.
• W1796764 cites W2044835159 @default.
• W1796764 cites W2045664576 @default.
• W1796764 cites W2047451726 @default.
• W1796764 cites W2049495196 @default.
• W1796764 cites W2049622511 @default.
• W1796764 cites W2052920877 @default.
• W1796764 cites W2054279604 @default.
• W1796764 cites W2055502462 @default.
• W1796764 cites W2055723678 @default.
• W1796764 cites W2059727295 @default.
• W1796764 cites W2060465418 @default.
• W1796764 cites W2061033200 @default.
• W1796764 cites W2062277952 @default.
• W1796764 cites W2066345617 @default.
• W1796764 cites W2067323173 @default.
• W1796764 cites W2067335202 @default.
• W1796764 cites W2068985481 @default.
• W1796764 cites W2071521217 @default.
• W1796764 cites W2073880004 @default.
• W1796764 cites W2077224224 @default.
• W1796764 cites W2078372474 @default.
• W1796764 cites W2078503449 @default.
• W1796764 cites W2081553142 @default.
• W1796764 cites W2081647388 @default.
• W1796764 cites W2082098561 @default.
• W1796764 cites W2082414821 @default.
• W1796764 cites W2084073492 @default.
• W1796764 cites W2084547258 @default.

• next