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• W1796778668 startingPage "2891" @default.
• W1796778668 abstract "El Tor and non-O1 strains of Vibrio cholerae were analyzed to determine whether synthesis of secreted hemolysin was influenced by the concentration of iron in the medium. Synthesis of hemolysin was found to be iron regulated in both El Tor and non-O1 isolates. Increased levels of hemolytic activity were detected in supernatants of iron-starved cells. Spontaneous hemolysin-deficient mutants of one non-O1 strain were found to occur at high frequency. These variants also failed to synthesize vibriobactin, the iron transport compound utilized by V. cholerae. Another non-O1 strain was found to synthesize both hemolysin and vibriobactin constitutively. When the cloned Escherichia coli fur gene, encoded on the plasmid pABN203, was introduced into this constitutive strain, normal iron regulation of both hemolysin and vibriobactin was reestablished. The ability of V. cholerae to utilize mammalian iron compounds was determined, and it was found that both hemin and hemoglobin could serve as sole sources of iron." @default.
• W1796778668 created "2016-06-24" @default.
• W1796778668 creator A5015384672 @default.
• W1796778668 creator A5060659632 @default.
• W1796778668 date "1988-11-01" @default.
• W1796778668 modified "2023-10-17" @default.
• W1796778668 title "Iron-regulated hemolysin production and utilization of heme and hemoglobin by Vibrio cholerae" @default.
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• W1796778668 doi "https://doi.org/10.1128/iai.56.11.2891-2895.1988" @default.
• W1796778668 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/259667" @default.
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