Matches in SemOpenAlex for { <https://semopenalex.org/work/W1796779887> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W1796779887 endingPage "427" @default.
- W1796779887 startingPage "418" @default.
- W1796779887 abstract "Recent studies suggest: that the epidermis and pilosebaceous epithelium are important sites of de novo sterol synthesis, and that the rate of cutaneous cholesterol synthesis does not change with alterations in circulating sterol levels. Since cutaneous sterols may be important for permeability barrier function, we studied the effect of experimentally altered barrier function on de novo sterologenesis in the epidermal and dermal layers of the skin. Epidermal sterologenesis appeared to be modulated by the skin's barrier requirements because topical detergent and acetone treatment stimulated de novo synthesis of nonsaponifiable lipids in the epidermis, but not in the dermis. Synthetic activity paralleled both the return of barrier function toward normal and the extent of prior damage to the barrier. Moreover, plastic-wrap occlusion of solvent-treated sites simultaneously corrected both the barrier abnormality and normalized sterol synthesis, further linking increased epidermal sterologenesis to barrier requirements. Whereas topical applications of a variety of other topical lipids did not down-regulate synthesis, epicutaneously applied 25-hydroxycholesterol appeared to diminish synthesis. These results suggest that maintenance of barrier function is one purpose of epidermal de novo nonsaponifiable lipid synthesis, and demonstrate further that, despite a lack of low density lipoprotein receptors, epidermis can regulate its lipid-synthetic apparatus in response to certain specific requirements." @default.
- W1796779887 created "2016-06-24" @default.
- W1796779887 creator A5008415248 @default.
- W1796779887 creator A5040146514 @default.
- W1796779887 creator A5050608918 @default.
- W1796779887 creator A5051847291 @default.
- W1796779887 creator A5087724918 @default.
- W1796779887 date "1985-04-01" @default.
- W1796779887 modified "2023-09-26" @default.
- W1796779887 title "De novo sterologenesis in the skin. II. Regulation by cutaneous barrier requirements." @default.
- W1796779887 cites W18663656 @default.
- W1796779887 cites W1973668507 @default.
- W1796779887 cites W2038975493 @default.
- W1796779887 cites W2047292886 @default.
- W1796779887 cites W2055302343 @default.
- W1796779887 cites W2059346921 @default.
- W1796779887 cites W2077814789 @default.
- W1796779887 cites W2080844332 @default.
- W1796779887 cites W2102742421 @default.
- W1796779887 cites W2111211507 @default.
- W1796779887 cites W2125936183 @default.
- W1796779887 cites W2169484065 @default.
- W1796779887 cites W2184641313 @default.
- W1796779887 cites W2216180461 @default.
- W1796779887 doi "https://doi.org/10.1016/s0022-2275(20)34355-8" @default.
- W1796779887 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4009060" @default.
- W1796779887 hasPublicationYear "1985" @default.
- W1796779887 type Work @default.
- W1796779887 sameAs 1796779887 @default.
- W1796779887 citedByCount "199" @default.
- W1796779887 countsByYear W17967798872012 @default.
- W1796779887 countsByYear W17967798872013 @default.
- W1796779887 countsByYear W17967798872014 @default.
- W1796779887 countsByYear W17967798872015 @default.
- W1796779887 countsByYear W17967798872016 @default.
- W1796779887 countsByYear W17967798872017 @default.
- W1796779887 countsByYear W17967798872018 @default.
- W1796779887 countsByYear W17967798872019 @default.
- W1796779887 countsByYear W17967798872020 @default.
- W1796779887 countsByYear W17967798872021 @default.
- W1796779887 countsByYear W17967798872022 @default.
- W1796779887 crossrefType "journal-article" @default.
- W1796779887 hasAuthorship W1796779887A5008415248 @default.
- W1796779887 hasAuthorship W1796779887A5040146514 @default.
- W1796779887 hasAuthorship W1796779887A5050608918 @default.
- W1796779887 hasAuthorship W1796779887A5051847291 @default.
- W1796779887 hasAuthorship W1796779887A5087724918 @default.
- W1796779887 hasBestOaLocation W17967798871 @default.
- W1796779887 hasConcept C16005928 @default.
- W1796779887 hasConcept C185592680 @default.
- W1796779887 hasConcept C2991981033 @default.
- W1796779887 hasConcept C71924100 @default.
- W1796779887 hasConcept C86803240 @default.
- W1796779887 hasConcept C95444343 @default.
- W1796779887 hasConceptScore W1796779887C16005928 @default.
- W1796779887 hasConceptScore W1796779887C185592680 @default.
- W1796779887 hasConceptScore W1796779887C2991981033 @default.
- W1796779887 hasConceptScore W1796779887C71924100 @default.
- W1796779887 hasConceptScore W1796779887C86803240 @default.
- W1796779887 hasConceptScore W1796779887C95444343 @default.
- W1796779887 hasIssue "4" @default.
- W1796779887 hasLocation W17967798871 @default.
- W1796779887 hasOpenAccess W1796779887 @default.
- W1796779887 hasPrimaryLocation W17967798871 @default.
- W1796779887 hasRelatedWork W1978720113 @default.
- W1796779887 hasRelatedWork W2106770861 @default.
- W1796779887 hasRelatedWork W2311116156 @default.
- W1796779887 hasRelatedWork W2315896585 @default.
- W1796779887 hasRelatedWork W2748952813 @default.
- W1796779887 hasRelatedWork W2899084033 @default.
- W1796779887 hasRelatedWork W4230846436 @default.
- W1796779887 hasRelatedWork W4250173351 @default.
- W1796779887 hasRelatedWork W4297184974 @default.
- W1796779887 hasRelatedWork W50221442 @default.
- W1796779887 hasVolume "26" @default.
- W1796779887 isParatext "false" @default.
- W1796779887 isRetracted "false" @default.
- W1796779887 magId "1796779887" @default.
- W1796779887 workType "article" @default.