Matches in SemOpenAlex for { <https://semopenalex.org/work/W1796786705> ?p ?o ?g. }
- W1796786705 endingPage "375" @default.
- W1796786705 startingPage "369" @default.
- W1796786705 abstract "To study signal transduction directed towards the cell nucleus and at the nuclear membranes, we investigated the association of protein kinase C (PKC) with nuclear membranes obtained from nuclei isolated from bovine brain. By use of phorbol-ester-binding assays, significant amounts of PKC could be demonstrated in nuclei and nuclear membranes. Nuclear membranes are shown to be able to activate purified PKC. The PKC endogenously present in nuclear membranes appears to be a so-called ‘membrane-inserted’ form: it is permanently active, still binds phorbol ester, but its activity is no longer dependent on Ca2+ and cannot be activated by phorbol ester. On the other hand, this form of PKC can be inhibited by specific PKC inhibitors. By using histone HIIIS and a specific peptide substrate, it could be shown that after extraction with Triton X-100 the PKC can be stimulated by phospholipid again. Immunoblot analysis with isoenzyme-specific antibodies revealed that the alpha- and gamma-isoenzymes, but not the beta-isoenzyme, are associated with membranes derived from brain nuclei." @default.
- W1796786705 created "2016-06-24" @default.
- W1796786705 creator A5020475421 @default.
- W1796786705 creator A5040769386 @default.
- W1796786705 creator A5047319254 @default.
- W1796786705 creator A5059673670 @default.
- W1796786705 creator A5062825190 @default.
- W1796786705 creator A5071142767 @default.
- W1796786705 date "1992-09-01" @default.
- W1796786705 modified "2023-10-16" @default.
- W1796786705 title "Properties of protein kinase C associated with nuclear membranes" @default.
- W1796786705 cites W1045314443 @default.
- W1796786705 cites W121512958 @default.
- W1796786705 cites W1480612082 @default.
- W1796786705 cites W1496172532 @default.
- W1796786705 cites W1505167649 @default.
- W1796786705 cites W1528398382 @default.
- W1796786705 cites W1534834744 @default.
- W1796786705 cites W1537213032 @default.
- W1796786705 cites W1544430323 @default.
- W1796786705 cites W1560197506 @default.
- W1796786705 cites W1579776952 @default.
- W1796786705 cites W1598863867 @default.
- W1796786705 cites W1605113644 @default.
- W1796786705 cites W1648924349 @default.
- W1796786705 cites W1748677511 @default.
- W1796786705 cites W1964839077 @default.
- W1796786705 cites W1970990475 @default.
- W1796786705 cites W1970991463 @default.
- W1796786705 cites W1973005880 @default.
- W1796786705 cites W1977672499 @default.
- W1796786705 cites W1988093399 @default.
- W1796786705 cites W1991714532 @default.
- W1796786705 cites W2005525303 @default.
- W1796786705 cites W2006404755 @default.
- W1796786705 cites W2008955076 @default.
- W1796786705 cites W2015648136 @default.
- W1796786705 cites W2018289835 @default.
- W1796786705 cites W2020641276 @default.
- W1796786705 cites W2028270197 @default.
- W1796786705 cites W2047743040 @default.
- W1796786705 cites W2065761783 @default.
- W1796786705 cites W2071103968 @default.
- W1796786705 cites W2076411911 @default.
- W1796786705 cites W2088072731 @default.
- W1796786705 cites W2091673674 @default.
- W1796786705 cites W2100837269 @default.
- W1796786705 cites W2155813411 @default.
- W1796786705 cites W2228774691 @default.
- W1796786705 cites W2239121165 @default.
- W1796786705 cites W2266799572 @default.
- W1796786705 cites W2291664211 @default.
- W1796786705 cites W2402649360 @default.
- W1796786705 cites W2420781371 @default.
- W1796786705 doi "https://doi.org/10.1042/bj2860369" @default.
- W1796786705 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1132907" @default.
- W1796786705 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1530569" @default.
- W1796786705 hasPublicationYear "1992" @default.
- W1796786705 type Work @default.
- W1796786705 sameAs 1796786705 @default.
- W1796786705 citedByCount "41" @default.
- W1796786705 countsByYear W17967867052012 @default.
- W1796786705 crossrefType "journal-article" @default.
- W1796786705 hasAuthorship W1796786705A5020475421 @default.
- W1796786705 hasAuthorship W1796786705A5040769386 @default.
- W1796786705 hasAuthorship W1796786705A5047319254 @default.
- W1796786705 hasAuthorship W1796786705A5059673670 @default.
- W1796786705 hasAuthorship W1796786705A5062825190 @default.
- W1796786705 hasAuthorship W1796786705A5071142767 @default.
- W1796786705 hasBestOaLocation W17967867052 @default.
- W1796786705 hasConcept C104317684 @default.
- W1796786705 hasConcept C119795356 @default.
- W1796786705 hasConcept C153911025 @default.
- W1796786705 hasConcept C181199279 @default.
- W1796786705 hasConcept C185592680 @default.
- W1796786705 hasConcept C195794163 @default.
- W1796786705 hasConcept C2777896290 @default.
- W1796786705 hasConcept C2780114586 @default.
- W1796786705 hasConcept C2780723820 @default.
- W1796786705 hasConcept C29512474 @default.
- W1796786705 hasConcept C41625074 @default.
- W1796786705 hasConcept C49805395 @default.
- W1796786705 hasConcept C55493867 @default.
- W1796786705 hasConcept C62478195 @default.
- W1796786705 hasConcept C86339819 @default.
- W1796786705 hasConcept C86803240 @default.
- W1796786705 hasConcept C95444343 @default.
- W1796786705 hasConceptScore W1796786705C104317684 @default.
- W1796786705 hasConceptScore W1796786705C119795356 @default.
- W1796786705 hasConceptScore W1796786705C153911025 @default.
- W1796786705 hasConceptScore W1796786705C181199279 @default.
- W1796786705 hasConceptScore W1796786705C185592680 @default.
- W1796786705 hasConceptScore W1796786705C195794163 @default.
- W1796786705 hasConceptScore W1796786705C2777896290 @default.
- W1796786705 hasConceptScore W1796786705C2780114586 @default.
- W1796786705 hasConceptScore W1796786705C2780723820 @default.
- W1796786705 hasConceptScore W1796786705C29512474 @default.
- W1796786705 hasConceptScore W1796786705C41625074 @default.