Matches in SemOpenAlex for { <https://semopenalex.org/work/W1796797893> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W1796797893 endingPage "12" @default.
- W1796797893 startingPage "106" @default.
- W1796797893 abstract "Radiation carcinogenesis is one of the major biological effects considered important in the risk assessment for space travel. Various biological model systems, including both cultured cells and animals, have been found useful for studying the carcinogenic effects of space radiations, which consist of energetic electrons, protons and heavy ions. The development of techniques for studying neoplastic cell transformation in culture has made it possible to examine the cellular and molecular mechanisms of radiation carcinogenesis. Cultured cell systems are thus complementary to animal models. Many investigators have determined the oncogenic effects of ionizing and nonionizing radiation in cultured mammalian cells. One of the cell systems used most often for radiation transformation studies is mouse embryonic cells (C3H10T1/2), which are easy to culture and give good quantitative dose-response curves. Relative biological effectiveness (RBE) for heavy ions with various energies and linear energy transfer (LET) have been obtained with this cell system. Similar RBE and LET relationship was observed by investigators for other cell systems. In addition to RBE measurements, fundamental questions on repair of sub- and potential oncogenic lesions, direct and indirect effect, primary target and lesion, the importance of cell-cell interaction and the role of oncogenes and tumor suppressor genes in radiogenic carcinogenesis have been studied, and interesting results have been found. Recently several human epithelial cell systems have been developed, and ionizing radiation have been shown to transform these cells. Oncogenic transformation of these cells, however, requires a long expression time and/or multiple radiation exposures. Limited experimental data indicate high-LET heavy ions can be more effective than low-LET radiation in inducing cell transformation. Cytogenetic and molecular analyses can be performed with cloned transformants to provide insights into basic genetic mechanism(s) of radiogenic transformation of human epithelial cells." @default.
- W1796797893 created "2016-06-24" @default.
- W1796797893 creator A5009806627 @default.
- W1796797893 creator A5032030157 @default.
- W1796797893 creator A5055277438 @default.
- W1796797893 creator A5081689401 @default.
- W1796797893 creator A5091719201 @default.
- W1796797893 date "1995-10-01" @default.
- W1796797893 modified "2023-09-26" @default.
- W1796797893 title "Radiogenic cell transformation and carcinogenesis." @default.
- W1796797893 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11538546" @default.
- W1796797893 hasPublicationYear "1995" @default.
- W1796797893 type Work @default.
- W1796797893 sameAs 1796797893 @default.
- W1796797893 citedByCount "0" @default.
- W1796797893 crossrefType "journal-article" @default.
- W1796797893 hasAuthorship W1796797893A5009806627 @default.
- W1796797893 hasAuthorship W1796797893A5032030157 @default.
- W1796797893 hasAuthorship W1796797893A5055277438 @default.
- W1796797893 hasAuthorship W1796797893A5081689401 @default.
- W1796797893 hasAuthorship W1796797893A5091719201 @default.
- W1796797893 hasConcept C111337013 @default.
- W1796797893 hasConcept C114246631 @default.
- W1796797893 hasConcept C11928243 @default.
- W1796797893 hasConcept C121332964 @default.
- W1796797893 hasConcept C121608353 @default.
- W1796797893 hasConcept C125118446 @default.
- W1796797893 hasConcept C126322002 @default.
- W1796797893 hasConcept C145148216 @default.
- W1796797893 hasConcept C1491633281 @default.
- W1796797893 hasConcept C152744366 @default.
- W1796797893 hasConcept C153385146 @default.
- W1796797893 hasConcept C178790620 @default.
- W1796797893 hasConcept C18231593 @default.
- W1796797893 hasConcept C185544564 @default.
- W1796797893 hasConcept C185592680 @default.
- W1796797893 hasConcept C2993273003 @default.
- W1796797893 hasConcept C31033888 @default.
- W1796797893 hasConcept C502942594 @default.
- W1796797893 hasConcept C509974204 @default.
- W1796797893 hasConcept C54355233 @default.
- W1796797893 hasConcept C555283112 @default.
- W1796797893 hasConcept C62520636 @default.
- W1796797893 hasConcept C71924100 @default.
- W1796797893 hasConcept C81885089 @default.
- W1796797893 hasConcept C86611320 @default.
- W1796797893 hasConcept C86803240 @default.
- W1796797893 hasConcept C95444343 @default.
- W1796797893 hasConceptScore W1796797893C111337013 @default.
- W1796797893 hasConceptScore W1796797893C114246631 @default.
- W1796797893 hasConceptScore W1796797893C11928243 @default.
- W1796797893 hasConceptScore W1796797893C121332964 @default.
- W1796797893 hasConceptScore W1796797893C121608353 @default.
- W1796797893 hasConceptScore W1796797893C125118446 @default.
- W1796797893 hasConceptScore W1796797893C126322002 @default.
- W1796797893 hasConceptScore W1796797893C145148216 @default.
- W1796797893 hasConceptScore W1796797893C1491633281 @default.
- W1796797893 hasConceptScore W1796797893C152744366 @default.
- W1796797893 hasConceptScore W1796797893C153385146 @default.
- W1796797893 hasConceptScore W1796797893C178790620 @default.
- W1796797893 hasConceptScore W1796797893C18231593 @default.
- W1796797893 hasConceptScore W1796797893C185544564 @default.
- W1796797893 hasConceptScore W1796797893C185592680 @default.
- W1796797893 hasConceptScore W1796797893C2993273003 @default.
- W1796797893 hasConceptScore W1796797893C31033888 @default.
- W1796797893 hasConceptScore W1796797893C502942594 @default.
- W1796797893 hasConceptScore W1796797893C509974204 @default.
- W1796797893 hasConceptScore W1796797893C54355233 @default.
- W1796797893 hasConceptScore W1796797893C555283112 @default.
- W1796797893 hasConceptScore W1796797893C62520636 @default.
- W1796797893 hasConceptScore W1796797893C71924100 @default.
- W1796797893 hasConceptScore W1796797893C81885089 @default.
- W1796797893 hasConceptScore W1796797893C86611320 @default.
- W1796797893 hasConceptScore W1796797893C86803240 @default.
- W1796797893 hasConceptScore W1796797893C95444343 @default.
- W1796797893 hasIssue "2" @default.
- W1796797893 hasLocation W17967978931 @default.
- W1796797893 hasOpenAccess W1796797893 @default.
- W1796797893 hasPrimaryLocation W17967978931 @default.
- W1796797893 hasRelatedWork W1796797893 @default.
- W1796797893 hasRelatedWork W1976542675 @default.
- W1796797893 hasRelatedWork W1987008525 @default.
- W1796797893 hasRelatedWork W2010831179 @default.
- W1796797893 hasRelatedWork W2122968754 @default.
- W1796797893 hasRelatedWork W2435595842 @default.
- W1796797893 hasRelatedWork W2752307697 @default.
- W1796797893 hasRelatedWork W3021065480 @default.
- W1796797893 hasRelatedWork W3135471502 @default.
- W1796797893 hasRelatedWork W2412361774 @default.
- W1796797893 hasVolume "8" @default.
- W1796797893 isParatext "false" @default.
- W1796797893 isRetracted "false" @default.
- W1796797893 magId "1796797893" @default.
- W1796797893 workType "article" @default.