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- W179764517 abstract "textabstractThe total number of different immunoglobulin (I g) molecules that theimmune system produces is often called the antibody specificity repertoireorB cell repertoire (Chapter 1). This repertoire can be subdivided intothree categories: the potential, the available and the actual repertoires.The potential repertoire is determined by the number, structure and mechanismsof expression of the germl ine genes encoding lg molecules plus thepossible somatic variants derived from them and can be regarded as whatpotentially can be made. The available repertoire is defined as the set ofdiverse antibody molecules that are expressed by immunocompetent but restingB lymphocytes and can be looked upon as what has been made and can be used.The actual repertoire is represented by that set of antibodies that is actuallysecreted by S cells and can be regarded as what is actually being used.Little is known about the regulatory mechanisms that enable the establishment,from the potential repertoire, of the available and functionallyexpressed repertoire of the immunocompetent resting B cell compartment. Similarly,the mechanisms that govern the establishment of the actual repertoirefrom the available repertoire are only partly known. Therefore~ the purposeof the studies presented in this thesis (as outlined in Chapter Ill) was toobtain more information concerning the regulatory mechanisms that are involvedin the functional expression of the lg C and V genes by murine B cells.To this end, frequency analyses of B cells secreting particular lg heavychain isotypes (C gene expression) and specific lgM antibodies (V gene expression)were performed among the progeny of B cells that had differentiatedfrom pre-S cells in vitro. The same analyses were performed on in vivo generatedmitogen-reactive S cells (available repertoire) and on the 1Spontaneously1occurring ( 1background') lg-secreting cells (actual repertoire). Thepossible regulating influences studied include age, T cells and exogenousantigens. The latter became feasible, since, with the successful breeding ofgermfree mice fed an ultrafiltered solution of chemically defined low molecularweight nutrients, exogenous stimuli such as antigens and mitogens canbe reduced to a minimum never attained before." @default.
- W179764517 created "2016-06-24" @default.
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- W179764517 date "1985-05-15" @default.
- W179764517 modified "2023-09-27" @default.
- W179764517 title "The mouse B cell repertoire : antibody specificities and immunoglobulin (sub) class distribution" @default.
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