FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1797788416> ?p ?o ?g. }

• W1797788416 endingPage "152" @default.
• W1797788416 startingPage "145" @default.
• W1797788416 abstract "The present study is aimed to enhance the oral bioavailability of ketoprofen by inserting it into the matrix of poly(vinylpyrrolidone) (PVP) K10 spatially confined into microcontainers, by means of supercritical CO2-aided impregnation. Microcontainers are cylindrical reservoirs, with typical sizes in the micrometer range, with a cavity open on one side, where the drug formulation is loaded. Differently to traditional tablets, microcontainers have a higher surface area per unit volume, and release the drug only in one direction. This design is meant to enhance the absorption of problematic drugs, like those with poor solubility in water. In a previous study we introduced a novel technique for drug loading of microcontainers, based on inkjet printing and supercritical impregnation (SCI). We showed that SCI produces accurate and reproducible drug loading for large arrays of microcontainers. In the attempt of enhancing the throughput of the loading methods, we propose the replacement of polymer inkjet printing with an easier manual compression of the PVP powder into the microcontainers. As the second step, the polymer powder filled-microcontainers were submitted to SCI. The separate role of different impregnation parameters (temperature, pressure, time, drug concentration in the supercritical phase) was elucidated with respect to the loading capacity. The microcontainer filling was observed by means of optical macroimaging, X-ray microtomography and scanning electron microscopy. The physical state of the drug was investigated by means of Raman spectroscopy and compared with selected representative PVP-ketoprofen physical mixtures. Finally, the drug loading was estimated by means of in vitro dissolution tests. The characterization study shows that the present loading method is a valuable alternative to the one previously described. The drug loading can be controlled with high accuracy and reproducibility and the impregnated drug is in amorphous state. These results demonstrate that SCI can be used as a high throughput loading technique for microfabricated devices for oral drug delivery." @default.
• W1797788416 created "2016-06-24" @default.
• W1797788416 creator A5004765351 @default.
• W1797788416 creator A5013539270 @default.
• W1797788416 creator A5015131739 @default.
• W1797788416 creator A5023057339 @default.
• W1797788416 creator A5036535149 @default.
• W1797788416 creator A5041268623 @default.
• W1797788416 creator A5049028647 @default.
• W1797788416 creator A5053561558 @default.
• W1797788416 creator A5058455344 @default.
• W1797788416 creator A5068091382 @default.
• W1797788416 creator A5070613747 @default.
• W1797788416 creator A5071220140 @default.
• W1797788416 creator A5081745541 @default.
• W1797788416 date "2016-01-01" @default.
• W1797788416 modified "2023-10-16" @default.
• W1797788416 title "Supercritical impregnation of polymer matrices spatially confined in microcontainers for oral drug delivery: Effect of temperature, pressure and time" @default.
• W1797788416 cites W1969778343 @default.
• W1797788416 cites W1999147494 @default.
• W1797788416 cites W2005684783 @default.
• W1797788416 cites W2006237542 @default.
• W1797788416 cites W2013133034 @default.
• W1797788416 cites W2013882553 @default.
• W1797788416 cites W2023788956 @default.
• W1797788416 cites W2026170139 @default.
• W1797788416 cites W2030156965 @default.
• W1797788416 cites W2043689225 @default.
• W1797788416 cites W2044829159 @default.
• W1797788416 cites W2055444002 @default.
• W1797788416 cites W2059357615 @default.
• W1797788416 cites W206031839 @default.
• W1797788416 cites W2070019739 @default.
• W1797788416 cites W2070870521 @default.
• W1797788416 cites W2073596338 @default.
• W1797788416 cites W2080496156 @default.
• W1797788416 cites W2085113776 @default.
• W1797788416 cites W2114120064 @default.
• W1797788416 cites W2115786024 @default.
• W1797788416 cites W2128627469 @default.
• W1797788416 cites W2153938037 @default.
• W1797788416 cites W2157812230 @default.
• W1797788416 cites W2169443538 @default.
• W1797788416 doi "https://doi.org/10.1016/j.supflu.2015.08.023" @default.
• W1797788416 hasPublicationYear "2016" @default.
• W1797788416 type Work @default.
• W1797788416 sameAs 1797788416 @default.
• W1797788416 citedByCount "27" @default.
• W1797788416 countsByYear W17977884162016 @default.
• W1797788416 countsByYear W17977884162017 @default.
• W1797788416 countsByYear W17977884162018 @default.
• W1797788416 countsByYear W17977884162019 @default.
• W1797788416 countsByYear W17977884162020 @default.
• W1797788416 countsByYear W17977884162021 @default.
• W1797788416 countsByYear W17977884162022 @default.
• W1797788416 crossrefType "journal-article" @default.
• W1797788416 hasAuthorship W1797788416A5004765351 @default.
• W1797788416 hasAuthorship W1797788416A5013539270 @default.
• W1797788416 hasAuthorship W1797788416A5015131739 @default.
• W1797788416 hasAuthorship W1797788416A5023057339 @default.
• W1797788416 hasAuthorship W1797788416A5036535149 @default.
• W1797788416 hasAuthorship W1797788416A5041268623 @default.
• W1797788416 hasAuthorship W1797788416A5049028647 @default.
• W1797788416 hasAuthorship W1797788416A5053561558 @default.
• W1797788416 hasAuthorship W1797788416A5058455344 @default.
• W1797788416 hasAuthorship W1797788416A5068091382 @default.
• W1797788416 hasAuthorship W1797788416A5070613747 @default.
• W1797788416 hasAuthorship W1797788416A5071220140 @default.
• W1797788416 hasAuthorship W1797788416A5081745541 @default.
• W1797788416 hasBestOaLocation W17977884161 @default.
• W1797788416 hasConcept C118419359 @default.
• W1797788416 hasConcept C120665830 @default.
• W1797788416 hasConcept C121332964 @default.
• W1797788416 hasConcept C127413603 @default.
• W1797788416 hasConcept C14029885 @default.
• W1797788416 hasConcept C155574463 @default.
• W1797788416 hasConcept C159985019 @default.
• W1797788416 hasConcept C171250308 @default.
• W1797788416 hasConcept C171635847 @default.
• W1797788416 hasConcept C178790620 @default.
• W1797788416 hasConcept C181389837 @default.
• W1797788416 hasConcept C185592680 @default.
• W1797788416 hasConcept C192562407 @default.
• W1797788416 hasConcept C2776035855 @default.
• W1797788416 hasConcept C2779820397 @default.
• W1797788416 hasConcept C2779849058 @default.
• W1797788416 hasConcept C2780744026 @default.
• W1797788416 hasConcept C42360764 @default.
• W1797788416 hasConcept C43617362 @default.
• W1797788416 hasConcept C521977710 @default.
• W1797788416 hasConcept C60644358 @default.
• W1797788416 hasConcept C86803240 @default.
• W1797788416 hasConcept C88380143 @default.
• W1797788416 hasConceptScore W1797788416C118419359 @default.
• W1797788416 hasConceptScore W1797788416C120665830 @default.
• W1797788416 hasConceptScore W1797788416C121332964 @default.
• W1797788416 hasConceptScore W1797788416C127413603 @default.
• W1797788416 hasConceptScore W1797788416C14029885 @default.

• next