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- W1797883911 abstract "Significance During branching morphogenesis of the developing lung, it is generally thought that a spatial template of biochemical cues determines the airway branching pattern. Here, however, we demonstrate that physical mechanisms can control the pattern of airway branching. Using a combination of 3D culture experiments and theoretical modeling, we show that a growth-induced physical instability initiates the formation of new epithelial branches. Tuning epithelial growth rate controls the dominant wavelength of the instability, and thereby the branching pattern. These findings emphasize the role of mechanical forces during morphogenesis and indicate that lung development is not a closed genetic system. Physical cues also regulate the spatially patterned cell behaviors that underlie organ assembly in the embryo." @default.
- W1797883911 created "2016-06-24" @default.
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- W1797883911 date "2015-07-13" @default.
- W1797883911 modified "2023-10-12" @default.
- W1797883911 title "Mechanically patterning the embryonic airway epithelium" @default.
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- W1797883911 doi "https://doi.org/10.1073/pnas.1504102112" @default.
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