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• W1798283220 abstract "Purpose . Radiotherapy is an effective treatment modality in the clinical treatment of breast cancer. The present work investigated the effect of 3,3′-diindolylmethane (DIM) on γ -irradiation sensitizing human breast carcinoma. Methods . Cell survival, intracellular ROS levels, cell cycle distribution, cell apoptosis, and expression of proteins related to apoptosis were measured with MTT assays, flow cytometry, and Western blot analysis, respectively. Results . In vitro DIM plus γ -irradiation arrested the activity of G2/M phase cell cycle, increased intracellular ROS level, significantly suppressed PARP (poly ADP-ribose polymerase), and enhanced γ -irradiation-induced apoptosis, thereby inhibiting the proliferation of MCF-7 cells. Conclusion . These data provide a rationale for the use of DIM as a promising sensitizer of γ -irradiation." @default.
• W1798283220 created "2016-06-24" @default.
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• W1798283220 date "2015-01-01" @default.
• W1798283220 modified "2023-09-25" @default.
• W1798283220 title "3,3′-Diindolylmethane: A Promising Sensitizer ofγ-Irradiation" @default.
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• W1798283220 doi "https://doi.org/10.1155/2015/465105" @default.
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