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- W1799116502 abstract "Cancer poses danger because of its unregulated growth, development of resistance, and metastatic spread to vital organs. We currently lack quantitative theory for how preventive measures and post-diagnostic interventions are predicted to affect risks of a life threatening cancer. Here we evaluate how continuous measures, such as life style changes and traditional treatments, affect both neoplastic growth and the frequency of resistant clones. We then compare and contrast preventive and post-diagnostic interventions assuming that only a single lesion progresses to invasive carcinoma during the life of an individual, and resection either leaves residual cells or metastases are undetected. Whereas prevention generally results in more positive therapeutic outcomes than post-diagnostic interventions, this advantage is substantially lowered should prevention initially fail to arrest tumour growth. We discuss these results and other important mitigating factors that should be taken into consideration in a comparative understanding of preventive and post-diagnostic interventions." @default.
- W1799116502 created "2016-06-24" @default.
- W1799116502 creator A5023284458 @default.
- W1799116502 creator A5066818460 @default.
- W1799116502 date "2015-06-25" @default.
- W1799116502 modified "2023-09-24" @default.
- W1799116502 title "Dynamics of preventive vs post-diagnostic cancer control using low-impact measures" @default.
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- W1799116502 doi "https://doi.org/10.7554/elife.06266" @default.
- W1799116502 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4524440" @default.
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