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• W1799175946 abstract "Abstract Saccharomyces cerevisiae subtelomeric repeats contain silencing elements such as the core X sequence, which is present at all chromosome ends. When transplaced at HML, core X can enhance the action of a distant silencer without acting as a silencer on its own, thus fulfilling the functional definition of a protosilencer. Here we show that an ACS motif and an Abf1p-binding site participate in the silencing capacity of core X and that their effects are additive. In addition, in a variety of settings, core X was found to bring about substantial gene repression only when a low level of silencing was already detectable in its absence. Adjoining an X-STAR sequence, which naturally abuts core X in subtelomeric regions, did not improve the silencing capacity of core X. We propose that protosilencers play a major role in a variety of silencing phenomena, as is the case for core X, which acts as a silencing relay, prolonging silencing propagation away from telomeres." @default.
• W1799175946 created "2016-06-24" @default.
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• W1799175946 date "2001-05-01" @default.
• W1799175946 modified "2023-10-01" @default.
• W1799175946 title "Protosilencers in <i>Saccharomyces cerevisiae</i> Subtelomeric Regions" @default.
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• W1799175946 doi "https://doi.org/10.1093/genetics/158.1.167" @default.
• W1799175946 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1461618" @default.
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• W1799175946 hasPublicationYear "2001" @default.
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