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- W1799296911 abstract "Lactobacilli are commensal microbes that reside in the intestines of several species, including chickens. Structural constituents of lactobacilli are able to stimulate the host immune system. Macrophages are crucial players in both innate and adaptive immune systems. Here, we investigated the effects of Lactobacillus acidophilus, Lactobacillus reuteri, Lactobacillus salivarius and their cell-free culture supernatants on the pro-inflammatory gene expression profile, nitric oxide (NO) production and phagocytosis by chicken macrophages. Substantial differences were found among Lactobacillus strains in their capacity to induce pro-inflammatory cytokines. L. acidophilus only up-regulated interferon (IFN)-γ, while L. reuteri and L. salivarius up-regulated interleukin (IL)-1β, IL-6, IL-8 and IL-12 expression. Supernatant of L. salivarius up-regulated IL-1β, IL-8 and IFN-γ expression, while the other cell-free supernatants did not induce significant changes. Moreover, L. reuteri and L. salivarius increased macrophage phagocytosis, but all cell-free supernatants increased macrophage NO production and did not change phagocytosis activity." @default.
- W1799296911 created "2016-06-24" @default.
- W1799296911 creator A5031465756 @default.
- W1799296911 creator A5033602198 @default.
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- W1799296911 date "2015-12-01" @default.
- W1799296911 modified "2023-09-24" @default.
- W1799296911 title "Lactobacillus and Lactobacillus cell-free culture supernatants modulate chicken macrophage activities" @default.
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- W1799296911 doi "https://doi.org/10.1016/j.rvsc.2015.10.005" @default.
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