FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1799346688> ?p ?o ?g. }

• W1799346688 endingPage "4280" @default.
• W1799346688 startingPage "4273" @default.
• W1799346688 abstract "Fibroblast growth factor (FGF) receptor (FGFR) gene family consists of at least four receptor tyrosine kinases that transduce signals important in a variety of developmental and physiological processes related to cell growth and differentiation. Here we have characterized the binding of different FGFs to FGFR-4. Our results establish an FGF binding profile for FGFR-4 with aFGF having the highest affinity, followed by K-FGF/hst-1 and bFGF. In addition, FGF-6 was found to bind to FGFR-4 in ligand competition experiments. Interestingly, the FGFR-4 gene was found to encode only the prototype receptor in a region where both FGFR-1 and FGFR-2 show alternative splicing leading to differences in their ligand binding specificities and to secreted forms of these receptors. Ligands binding to FGFR-4 induced receptor autophosphorylation and phosphorylation of a set of cellular polypeptides, which differed from those phosphorylated in FGFR-1-expressing cells. Specifically, the FGFR-1-expressing cells showed a considerably more extensive tyrosine phosphorylation of PLC-gamma than the FGFR-4-expressing cells. Structural and functional specificity within the FGFR family exemplified by FGFR-4 may help to explain how FGFs perform their diverse functions." @default.
• W1799346688 created "2016-06-24" @default.
• W1799346688 creator A5004109045 @default.
• W1799346688 creator A5004770500 @default.
• W1799346688 creator A5010996325 @default.
• W1799346688 creator A5033716671 @default.
• W1799346688 creator A5052976570 @default.
• W1799346688 creator A5067451409 @default.
• W1799346688 creator A5073403483 @default.
• W1799346688 creator A5091002644 @default.
• W1799346688 date "1992-12-01" @default.
• W1799346688 modified "2023-10-18" @default.
• W1799346688 title "Fibroblast growth factor receptor-4 shows novel features in genomic structure, ligand binding and signal transduction." @default.
• W1799346688 cites W1531144136 @default.
• W1799346688 cites W1784257340 @default.
• W1799346688 cites W1828331863 @default.
• W1799346688 cites W1881900550 @default.
• W1799346688 cites W1890507836 @default.
• W1799346688 cites W1892096673 @default.
• W1799346688 cites W1940527094 @default.
• W1799346688 cites W1967149115 @default.
• W1799346688 cites W1968610357 @default.
• W1799346688 cites W1974873948 @default.
• W1799346688 cites W1984648137 @default.
• W1799346688 cites W1998835611 @default.
• W1799346688 cites W2005529016 @default.
• W1799346688 cites W2008922304 @default.
• W1799346688 cites W2008980811 @default.
• W1799346688 cites W2011403484 @default.
• W1799346688 cites W2017724386 @default.
• W1799346688 cites W2020589708 @default.
• W1799346688 cites W2027737655 @default.
• W1799346688 cites W2029503020 @default.
• W1799346688 cites W2033489993 @default.
• W1799346688 cites W2033785962 @default.
• W1799346688 cites W2036895735 @default.
• W1799346688 cites W2042202567 @default.
• W1799346688 cites W2045718139 @default.
• W1799346688 cites W2053717197 @default.
• W1799346688 cites W2055828195 @default.
• W1799346688 cites W2061848914 @default.
• W1799346688 cites W2074641624 @default.
• W1799346688 cites W2081029926 @default.
• W1799346688 cites W2082496437 @default.
• W1799346688 cites W2086103921 @default.
• W1799346688 cites W2088775512 @default.
• W1799346688 cites W2099543104 @default.
• W1799346688 cites W2118830070 @default.
• W1799346688 cites W2151598389 @default.
• W1799346688 cites W2199620244 @default.
• W1799346688 cites W2308806306 @default.
• W1799346688 cites W2336697595 @default.
• W1799346688 cites W2411135442 @default.
• W1799346688 cites W2412203941 @default.
• W1799346688 cites W4255042798 @default.
• W1799346688 cites W986709771 @default.
• W1799346688 doi "https://doi.org/10.1002/j.1460-2075.1992.tb05526.x" @default.
• W1799346688 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/557000" @default.
• W1799346688 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1385111" @default.
• W1799346688 hasPublicationYear "1992" @default.
• W1799346688 type Work @default.
• W1799346688 sameAs 1799346688 @default.
• W1799346688 citedByCount "159" @default.
• W1799346688 countsByYear W17993466882012 @default.
• W1799346688 countsByYear W17993466882013 @default.
• W1799346688 countsByYear W17993466882014 @default.
• W1799346688 countsByYear W17993466882015 @default.
• W1799346688 countsByYear W17993466882017 @default.
• W1799346688 countsByYear W17993466882018 @default.
• W1799346688 countsByYear W17993466882019 @default.
• W1799346688 countsByYear W17993466882021 @default.
• W1799346688 countsByYear W17993466882022 @default.
• W1799346688 countsByYear W17993466882023 @default.
• W1799346688 crossrefType "journal-article" @default.
• W1799346688 hasAuthorship W1799346688A5004109045 @default.
• W1799346688 hasAuthorship W1799346688A5004770500 @default.
• W1799346688 hasAuthorship W1799346688A5010996325 @default.
• W1799346688 hasAuthorship W1799346688A5033716671 @default.
• W1799346688 hasAuthorship W1799346688A5052976570 @default.
• W1799346688 hasAuthorship W1799346688A5067451409 @default.
• W1799346688 hasAuthorship W1799346688A5073403483 @default.
• W1799346688 hasAuthorship W1799346688A5091002644 @default.
• W1799346688 hasBestOaLocation W17993466882 @default.
• W1799346688 hasConcept C101544691 @default.
• W1799346688 hasConcept C11960822 @default.
• W1799346688 hasConcept C150109051 @default.
• W1799346688 hasConcept C153911025 @default.
• W1799346688 hasConcept C170493617 @default.
• W1799346688 hasConcept C42362537 @default.
• W1799346688 hasConcept C55493867 @default.
• W1799346688 hasConcept C62478195 @default.
• W1799346688 hasConcept C74373430 @default.
• W1799346688 hasConcept C82867764 @default.
• W1799346688 hasConcept C86803240 @default.
• W1799346688 hasConcept C95444343 @default.
• W1799346688 hasConcept C97029542 @default.
• W1799346688 hasConceptScore W1799346688C101544691 @default.
• W1799346688 hasConceptScore W1799346688C11960822 @default.

• next